5-环丙基-2H-1,2,3,4-四唑合成路线 （共 2 条）
反应条件
1: With sodium azide; triethyl amine hydrochloride in toluene T=110°C; 24 h; Inert atmosphere; 2: With hydrogenchloride in water pH=1 - 2;
参考文献
MERCK SERONO S.A.; SWINNEN, Dominique; JORAND-LEBRUN, Catherine; GRIPPI-VALLOTTON, Tania; GERBER, Patrick; GONZALEZ, Jerome; SHAW, Jeffrey; JEYAPRAKASHNARAYANAN, Seenisamy
Patent: WO2010/100144 A1, 2010 ;
Location in patent: Page/Page column 116-117 ;
WO 2010/100144 A1
反应条件
1: 5-cyclopropyl-1H-tetrazole With 18-crown-6 ether; potassium tert-butylate in tetrahydrofuran; 1,4-dioxane
0.25 h;
2: 2-(chloromethyl)-4-fluoroaniline in tetrahydrofuran; 1,4-dioxane
T=60°C; 18 h;
参考文献
GLAXO GROUP LIMTED
Patent: WO2007/14054 A2, 2007 ;
Location in patent: Page/Page column 29-30 ;
WO 2007/014054 A2
