alpha-氯-N-(苯基甲基)-苯乙酰胺合成路线 （共 8 条）
反应条件
thionyl chloride in dichloromethane T=0 - 20°C;
参考文献
Koszelewski, Dominik; Cwiklak, Malgorzata; Ostaszewski, Ryszard
Tetrahedron Asymmetry, 2012 , vol. 23, # 17 p. 1256 - 1261
反应条件
1: 77 percent / Et3N / CH2Cl2 / 1 h / Ambient temperature 2: 74 percent / triethylammonium hydrochloride, triethylamine, MsCl / CH2Cl2 / 1) 0 deg C, 30 min, 2) r.t. View Scheme
参考文献
Hoffman, Ribert V.; Nayyar, Naresh K.; Chen, Wenting
Journal of Organic Chemistry, 1992 , vol. 57, # 21 p. 5700 - 5707
反应条件
1: 77 percent / Et3N / CH2Cl2 / 1 h / Ambient temperature 2: 74 percent / triethylammonium hydrochloride, triethylamine, MsCl / CH2Cl2 / 1) 0 deg C, 30 min, 2) r.t. View Scheme
参考文献
Hoffman, Ribert V.; Nayyar, Naresh K.; Chen, Wenting
Journal of Organic Chemistry, 1992 , vol. 57, # 21 p. 5700 - 5707
反应条件
1: 1.) LiAlH4 / 1.) THF, RT, 30 min, 2.) THF, RT, 20 h 2: 83 percent / pyridine / 0.5 h / Ambient temperature 3: 83 percent / n-Bu4NCl / benzene / 2 h / Heating View Scheme
参考文献
Choi, Daeock; Stables, James P.; Kohn, Harold
Bioorganic and Medicinal Chemistry, 1996 , vol. 4, # 12 p. 2105 - 2114
反应条件
1: 1.) LiAlH4 / 1.) THF, RT, 30 min, 2.) THF, RT, 20 h 2: 83 percent / pyridine / 0.5 h / Ambient temperature 3: 83 percent / n-Bu4NCl / benzene / 2 h / Heating View Scheme
参考文献
Choi, Daeock; Stables, James P.; Kohn, Harold
Bioorganic and Medicinal Chemistry, 1996 , vol. 4, # 12 p. 2105 - 2114
反应条件
1: 50percent aq. NaOH / triethylbenzylammonium chloride / 0.5 h / 50 °C 2: H2O / 0.5 h / Heating View Scheme
参考文献
Petrov, Orlin S.; Ognyanov, Vassil I.; Mollov, Nikola M.
Synthesis, 1987 , # 7 p. 637 - 638
反应条件
1.1: sodium hydroxide / water; methanol / 0.5 h / |Sonication 1.2: pH 7 2.1: thionyl chloride / dichloromethane / 0 - 20 °C View Scheme
参考文献
Koszelewski, Dominik; Cwiklak, Malgorzata; Ostaszewski, Ryszard
Tetrahedron Asymmetry, 2012 , vol. 23, # 17 p. 1256 - 1261
反应条件
sodium hydroxide; diethyl ether
参考文献
Beguin, Cecile; LeTiran, Arnaud; Stables, James P.; Voyksner, Robert D.; Kohn, Harold
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 11 p. 3079 - 3096
