5-氟-2',3'-异亚丙基尿苷合成路线 （共 11 条）
反应条件
toluene-4-sulfonic acid in acetone Ambient temperature;
参考文献
Watanabe, K. A.; Matsuda, A.; Halat, M. J.; Hollenberg, D. H.; Nisselbaum, J. S.; Fox, J. J.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 7 p. 893 - 897
反应条件
sulfuric acid T=0 - 20°C; Inert atmosphere;
参考文献
Bello, Angelica M.; Konforte, Danijela; Poduch, Ewa; Furlonger, Caren; Wei, Lianhu; Liu, Yan; Lewis, Melissa; Pai, Emil F.; Paige, Christopher J.; Kotra, Lakshmi P.
Journal of Medicinal Chemistry, 2009 , vol. 52, # 6 p. 1648 - 1658
反应条件
p-toluenesulfonic acid monohydrate in acetone 1.66667 h; Heating / reflux;
参考文献
HEIDELBERG PHARMA GMBH
Patent: US2008/14258 A1, 2008 ;
Location in patent: Page/Page column 2-3 ;
反应条件
aluminium trichloride; methoxybenzene Ambient temperature;
参考文献
Akiyama, Takahiko; Kumegawa, Masahiro; Takesue, Yasuhiro; Nishimoto, Hiroyuki; Ozaki, Shoichiro
Chemistry Letters, 1990 , # 3 p. 339 - 342
反应条件
1: N,N-dimethylaminopyridine 2: 83 percent / Et3N / methanol; H2O 3: 79 percent 4: 1.) CF3OF; 2.) Et3N / 1.) CCl3F; 2.) MeOH, H2O View Scheme
参考文献
Schwartz, Herbert M.; MacCoss, Malcolm; Danyluk, Steven S.
Magnetic Resonance in Chemistry, 1985 , vol. 23, # 11 p. 885 - 894
反应条件
1: NaH, H2(17)O (54.75percent) / dimethylformamide 2: 1.) CF3OF; 2.) Et3N / 1.) CCl3F; 2.) MeOH, H2O View Scheme
参考文献
Schwartz, Herbert M.; MacCoss, Malcolm; Danyluk, Steven S.
Magnetic Resonance in Chemistry, 1985 , vol. 23, # 11 p. 885 - 894
反应条件
1: 83 percent / Et3N / methanol; H2O 2: 79 percent 3: 1.) CF3OF; 2.) Et3N / 1.) CCl3F; 2.) MeOH, H2O View Scheme
参考文献
Schwartz, Herbert M.; MacCoss, Malcolm; Danyluk, Steven S.
Magnetic Resonance in Chemistry, 1985 , vol. 23, # 11 p. 885 - 894
反应条件
1: H2(17)O (54.75percent) / CHCl3 2: 83 percent / Et3N / methanol; H2O 3: 79 percent 4: 1.) CF3OF; 2.) Et3N / 1.) CCl3F; 2.) MeOH, H2O View Scheme
参考文献
Schwartz, Herbert M.; MacCoss, Malcolm; Danyluk, Steven S.
Magnetic Resonance in Chemistry, 1985 , vol. 23, # 11 p. 885 - 894
反应条件
trifluoromethyl hypofluorite; triethylamine 1.) CCl3F; 2.) MeOH, H2O; Yield given. Multistep reaction;
参考文献
Schwartz, Herbert M.; MacCoss, Malcolm; Danyluk, Steven S.
Magnetic Resonance in Chemistry, 1985 , vol. 23, # 11 p. 885 - 894
反应条件
1: 1-dodecylthio-2-decyloxypropyl-3-phosphatidic acid With 2,4,6-triisopropyl benzene sulphonyl chloride in pyridine T=20 - 25°C; 2 h; 2: 5-fluorouridine-2,3-isopropylidene derivative in pyridine T=20 - 25°C; 16 h;
参考文献
HEIDELBERG PHARMA GMBH
Patent: US2008/14258 A1, 2008 ;
Location in patent: Page/Page column 3 ;
