1-(3-溴丙氧基)-4-氯苯合成路线 （共 9 条）
反应条件
1: 4-chloro-phenol With sodium n-propanolate in propan-1-ol 2: 1,3-dibromo-propane in propan-1-ol T=60°C; 6 h; Reflux;
参考文献
Lazewska, Dorota; Kuder, Kamil; Ligneau, Xavier; Camelin, Jean-Claude; Schunack, Walter; Stark, Holger; Kiec-Kononowicz, Katarzyna
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 8 p. 3037 - 3042
反应条件
1: With sodium hydride in DMF (N,N-dimethyl-formamide) T=0°C; 0.5 h; 2: With 1,3-dibromo-propane in DMF (N,N-dimethyl-formamide) T=20°C; 18 h;
参考文献
Montana, John Gary; Baxter, Andrew Douglas; Owen, David Alan; Watson, Robert John
Patent: US2003/236416 A1, 2003 ;
Location in patent: Page 6 ;
反应条件
sodium hydroxide; tetra(n-butyl)ammonium hydrogen sulphate in ethyl acetate
参考文献
Jacobus, David P.; Jensen, Norman P.
Patent: US2003/40544 A1, 2003 ;
反应条件
in N-methyl-acetamide
参考文献
H. Lundbeck A/S
Patent: US2003/50306 A1, 2003 ;
反应条件
1: NaOH / H2O / Heating 2: 61 percent / BuLi / tetrahydrofuran; hexane / 0.5 h / -100 °C View Scheme
参考文献
Bradsher, Charles K.; Reames, David C.
Journal of Organic Chemistry, 1981 , vol. 46, # 7 p. 1384 - 1388
反应条件
in methanol 3 h; Irradiation;
参考文献
Tetrahedron Letters, , vol. 21, p. 2911 - 2914
反应条件
1: sodium ethylate; ethanol / Erwaermen des Reaktionsprodukts mit wss. Kalilauge
2: 180 °C / 10 Torr
View Scheme
参考文献
Gaimster
Journal of the Science of Food and Agriculture, 1956 , vol. 7, p. 320,323
参考文献
Sheng, Chunquan; Wang, Wenya; Che, Xiaoying; Dong, Guoqiang; Wang, Shengzheng; Ji, Haitao; Miao, Zhenyuan; Yao, Jianzhong; Zhang, Wannian
ChemMedChem, 2010 , vol. 5, # 3 p. 390 - 397
反应条件
in toluene
T=85°C; 2 h;
参考文献
Capuano, Ben; Crosby, Ian T.; McRobb, Fiona M.; Podloucka, Anna; Taylor, David A.; Vom, Amelia; Yuriev, Elizabeth
Australian Journal of Chemistry, 2010 , vol. 63, # 1 p. 116 - 124
