2’-羟基-4-氯苯乙酮合成路线 （共 36 条）
反应条件
1.1: isopropylmagnesium chloride / tetrahydrofuran / 1.17 h / 20 - 30 °C / Inert atmosphere 1.2: 0 - 20 °C / Inert atmosphere 1.3: 30 °C / Inert atmosphere 2.1: hydrogenchloride; water / methanol / 40 °C / Inert atmosphere View Scheme
参考文献
McLaughlin, Mark; Belyk, Kevin M.; Qian, Gang; Reamer, Robert A.; Chen, Cheng-Yi
Journal of Organic Chemistry, 2012 , vol. 77, # 11 p. 5144 - 5148
反应条件
toluene-4-sulfonic acid in tetrahydrofuran; water 4.5 h; Reflux;
参考文献
Liu, Hui; Dong, Chao; Zhang, Zeguang; Wu, Peiyu; Jiang, Xuefeng
Angewandte Chemie - International Edition, 2012 , vol. 51, # 50 p. 12570 - 12574
Angew. Chem., 2012 , vol. 124, # 50 p. 12738 - 12742,5
反应条件
1: sodium chloride / acetonitrile 2: methanol / 25 °C View Scheme
参考文献
Tagawa, Kohei; Sasagawa, Keita; Wakisaka, Ken; Monjiyama, Shunsuke; Katayama, Mika; Yamataka, Hiroshi
Bulletin of the Chemical Society of Japan, 2014 , vol. 87, # 1 p. 119 - 126
反应条件
in dichloromethane 17 h; Ambient temperature;
参考文献
Boyer, Joseph H.; Natesh, Anbazhagan
Synthesis, 1988 , # 12 p. 980 - 981
反应条件
perchloric acid; water T=20°C; other reagent, kinetic solvent isotope effect; Rate constant;
参考文献
Kirkovskii, L. I.; Chapishev, S. V.
Doklady Chemistry, 1986 , vol. 291, p. 477 - 480
Dokl. Akad. Nauk SSSR Ser. Khim., 1986 , vol. 291, # 4 p. 874 - 877
反应条件
18-crown-6 ether; oxygen; potassium carbonate in water T=80°C; P=760.051 Torr; 10 h;
参考文献
Angewandte Chemie - International Edition, , vol. 51, # 50 p. 12570 - 12574
Angew. Chem., , vol. 124, # 50 p. 12738 - 12742,5
参考文献
Weidenhagen; Herrmann; Wegner
Chemische Berichte, 1937 , vol. 70, p. 575
反应条件
in water T=20 - 30°C; Mechanism;
参考文献
Russian Journal of Physical Chemistry, , vol. 58, # 12 p. 1823 - 1826
Zhurnal Fizicheskoi Khimii, , vol. 58, p. 3006 - 3009
反应条件
hydrogen; chiral iridium(III) complex in methanol T=60°C; P=7600.51 Torr; 15 h;
参考文献
Ohkuma, Takeshi; Utsumi, Noriyuki; Watanabe, Masahito; Tsutsumi, Kunihiko; Arai, Noriyoshi; Murata, Kunihiko
Organic Letters, 2007 , vol. 9, # 13 p. 2564 - 2567
反应条件
phosphorus pentoxide in chloroform 1 h; Ambient temperature;
参考文献
Ogata, Masaru; Matsumoto, Hiroshi; Shimizu, Sumio; Kida, Shiro; Shiro, Motoo; Tawara, Katsuya
European Journal of Medicinal Chemistry, 1989 , vol. 24, p. 137 - 144
