2-氨基-5-(4-氯苯基)-1,3,4-噻二唑合成路线 （共 12 条）
反应条件
1: With trichlorophosphate 3 h; Reflux; 2: With water 4 h; Reflux; 3: With potassium hydroxide in water
参考文献
Asian Journal of Chemistry, , vol. 22, # 7 p. 5289 - 5296
反应条件
methanesulfonic acid 1) 15 min, 25 deg C 2) reflux 4 h;
参考文献
Journal of Heterocyclic Chemistry, , vol. 17, p. 607 - 608
反应条件
anhydrous iron chloride in water 0.05 h; Microwave irradiationSonicationGreen chemistry;
参考文献
Monatshefte fur Chemie, , vol. 144, # 5 p. 681 - 686
反应条件
1: in ethanol Reflux; 2: With sulfuric acid in ethanol T=20°C;
参考文献
RSC Advances, , vol. 3, # 19 p. 6813 - 6816
反应条件
1: sodium acetate / water / 20 °C 2: anhydrous iron chloride; sodium acetate / acetic acid / 0.5 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 19 p. 5735 - 5738
反应条件
T=200°C; 0.333333 h;
参考文献
Journal of Heterocyclic Chemistry, , vol. 21, p. 1689 - 1698
反应条件
trifluoroacetic acid 60 h; Heating;
参考文献
European Journal of Medicinal Chemistry, , vol. 22, # 5 p. 467 - 471
反应条件
1: hydrazine hydrate / ethanol / Reflux 2: hydrogenchloride / water / Heating 3: sulfuric acid View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 16 p. 4919 - 4923
反应条件
1: hydrogenchloride / water / Heating 2: sulfuric acid View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 16 p. 4919 - 4923
反应条件
1: sodium hydrogencarbonate / acetone / 0 - 20 °C 2: sulfuric acid / 4 h / 20 °C View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 69, p. 931 - 941
