4-((叔丁氧基羰基)氨基)烟酸甲酯合成路线 （共 4 条）
反应条件
N-iodo-succinimide; potassium carbonate T=20°C; 1 h;
参考文献
CYTOKINETICS, INC.; SMITHKLINE BEECHAM CORPORATION
Patent: WO2003/103575 A2, 2003 ;
Location in patent: Page 74 ;
反应条件
in methanol; hexane 0.25 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2005/49604 A2, 2005 ;
Location in patent: Page/Page column 107 ;
WO 2005/049604 A2
反应条件
1: With sodium hydroxide; water in 1,4-dioxane T=60°C; 1 h; 2: With hydrogenchloride in 1,4-dioxane; water
参考文献
TIBOTEC PHARMACEUTICALS LTD
Patent: WO2006/100310 A1, 2006 ;
Location in patent: Page/Page column 34 ;
反应条件
trifluoroacetic acid in dichloromethane T=20°C; 2 h;
参考文献
CYTOKINETICS, INC.; SMITHKLINE BEECHAM CORPORATION
Patent: WO2003/103575 A2, 2003 ;
Location in patent: Page 74 ;
