4-氯羰基-哌啶-1-羧酸叔丁酯合成路线 （共 9 条）
反应条件
hydrogenchloride in 1,4-dioxane T=20°C;
参考文献
Eli Lilly and Company
Patent: US6660739 B1, 2003 ;
Location in patent: Page column 18 ;
反应条件
pyridine; thionyl chloride in dichloromethane T=20°C; Substitution; 0.416667 h;
参考文献
EURO-CELTIQUE S.A.
Patent: WO2007/28638 A1, 2007 ;
Location in patent: Page/Page column 94-95 ;
WO 2007/028638 A1
参考文献
Alanine, Alexander; Flohr, Alexander; Miller, Aubry Kern; Norcross, Roger David; Riemer, Claus
Patent: US2002/45615 A1, 2002 ;
反应条件
3 h; Heating / reflux;
参考文献
BOEHRINGER INGELHEIM PHARMACEUTICALS, INC.
Patent: WO2003/103661 A1, 2003 ;
Location in patent: Page 121-122 ;
WO 03/103661 A1
反应条件
1: potassium carbonate / water; tetrahydrofuran / 0 - 20 °C / |Schlenk technique; |Inert atmosphere 2: thionyl chloride; triethylamine / dichloromethane / 17 h / 20 °C / |Inert atmosphere; |Schlenk technique View Scheme
参考文献
Fuentes, Jose A.; Carpenter, Ian; Kann, Nina; Clarke, Matthew L.
Chemical Communications, 2013 , vol. 49, # 87 p. 10245 - 10247
反应条件
1: potassium carbonate / water; tetrahydrofuran / 0 - 20 °C / |Schlenk technique; |Inert atmosphere 2: thionyl chloride; triethylamine / dichloromethane / 17 h / 20 °C / |Inert atmosphere; |Schlenk technique View Scheme
参考文献
Fuentes, Jose A.; Carpenter, Ian; Kann, Nina; Clarke, Matthew L.
Chemical Communications, 2013 , vol. 49, # 87 p. 10245 - 10247
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine in tetrahydrofuran T=0 - 20°C; 24 h;
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Patent: WO2007/89031 A1, 2007 ;
Location in patent: Page/Page column 95 ;
WO 2007/089031 A1
反应条件
sodium hydroxide in water; toluene T=20°C; Product distribution / selectivity;
参考文献
Aventis Pharmaceuticals, Inc.; Hoechst Marion Roussel Deutschland GmbH
Patent: EP1734037 A2, 2006 ;
Location in patent: Page/Page column 58 ;
反应条件
1.1: triethylamine / dichloromethane / 6 h / 0 - 20 °C / |Inert atmosphere; |Schlenk technique 2.1: n-butyllithium / tetrahydrofuran; hexane / 2.75 h / 0 - 20 °C / |Inert atmosphere; |Schlenk technique 2.2: 21 h / -20 - 20 °C / |Schlenk technique; |Inert atmosphere 3.1: trifluoroacetic acid / dichloromethane / 22 h / 20 °C / |Inert atmosphere; |Schlenk technique 4.1: sodium tetrahydroborate / ethanol / |Inert atmosphere View Scheme
参考文献
Fuentes, Jose A.; Carpenter, Ian; Kann, Nina; Clarke, Matthew L.
Chemical Communications, 2013 , vol. 49, # 87 p. 10245 - 10247
