3,5-二羟基-4-甲基苯甲酸合成路线 （共 22 条）
反应条件
1: aqueous NaOH 2: aqueous HI; red phosphorus View Scheme
参考文献
Birkinshaw et al.
Biochemical Journal, 1952 , vol. 50, p. 610,624
反应条件
1: fuming H2SO4 / 8 h / 170 °C 2: 40 percent / 1.) KOH, NaOH, water 2.) conc. HCl / 1.) 140 deg C, 0.5 h; 250 deg C, 1.5 h; 265 deg C, 0.75 h; allowed to cool to 200 deg C View Scheme
参考文献
Martin; Vogel
Tetrahedron, 1980 , vol. 36, # 6 p. 791 - 794
反应条件
T=170 - 180°C; Verschmelzen mit Kaliumhydroxyd bei 250-270grad;
参考文献
Charlesworth; Robinson
Journal of the Chemical Society, 1934 , p. 1531
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Senderens; Aboulenc
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1928 , vol. 186, p. 1499
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Asahina; Asano
Chemische Berichte, 1933 , vol. 66, p. 687
Yakugaku Zasshi, 1933 , vol. 53, p. 1184
参考文献
Asahina; Hayashi
Yakugaku Zasshi, 1933 , vol. 53, p. 1279,1288
Chemische Berichte, 1933 , vol. 66, p. 1023,1026
参考文献
Benington,F. et al.
Journal of Organic Chemistry, 1960 , vol. 25, p. 2066 - 2067
反应条件
sulfuric acid T=120°C;
参考文献
Schunck; Marchlewski
Journal of the Chemical Society, 1894 , vol. 65, p. 185
反应条件
1: 89 percent / conc. H2SO4 / 18 h / Heating 2: 1.) AlCl3, HCl / 1.) 0 deg C, 6 h, ether; 2.) 70 deg C, 1 h, water 3: 81 percent / K2CO3 / acetone / 1.5 h / Heating 4: 1.) NaBH4; 2.) 2N NaOH 3.) 2N HCl / 1.) MeOH, 25 deg C, 0.5 h; 2.) 60 deg C, 0.25 h 5: 73 percent / K2CO3 / acetone / 18 h / Heating 6: 77 percent / LAH / diethyl ether / 2 h / Heating View Scheme
参考文献
Martin; Vogel
Tetrahedron, 1980 , vol. 36, # 6 p. 791 - 794
反应条件
1: 89 percent / conc. H2SO4 / 18 h / Heating
2: 1.) AlCl3, HCl / 1.) 0 deg C, 6 h, ether; 2.) 70 deg C, 1 h, water
3: 81 percent / K2CO3 / acetone / 1.5 h / Heating
4: 1.) NaBH4; 2.) 2N NaOH 3.) 2N HCl / 1.) MeOH, 25 deg C, 0.5 h; 2.) 60 deg C, 0.25 h
5: 73 percent / K2CO3 / acetone / 18 h / Heating
View Scheme
参考文献
Martin; Vogel
Tetrahedron, 1980 , vol. 36, # 6 p. 791 - 794
反应条件
potassium carbonate in acetone
T=40°C;
参考文献
Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Patent: EP2199295 A1, 2010 ;
Location in patent: Page/Page column 17 ;
反应条件
potassium carbonate in acetone
18 h; Heating;
参考文献
Cutler, Horace G.; Majetich, George; Tian, Xinrong; Spearing, Paul
Journal of Agricultural and Food Chemistry, 1997 , vol. 45, # 4 p. 1422 - 1429
