4(4-三氟甲氧基苯氧基哌啶)合成路线 （共 5 条）
反应条件
in 1,4-dioxane; diethyl ether
参考文献
G. D. Searle and Company
Patent: US6372758 B1, 2002 ;
US 6372758 B1
反应条件
1: benzene 2: KOH / ethanol View Scheme
参考文献
Kumar, S.T.V.S. Kiran; Sharma; Srivastava, Shipra; Bhandari, Kalpana; Shander, Girija; Singh
Medicinal Chemistry Research, 2004 , vol. 13, # 6-7 p. 518 - 527
反应条件
1: sodium hydride / N,N-dimethyl-acetamide 2: benzene 3: KOH / ethanol View Scheme
参考文献
Kumar, S.T.V.S. Kiran; Sharma; Srivastava, Shipra; Bhandari, Kalpana; Shander, Girija; Singh
Medicinal Chemistry Research, 2004 , vol. 13, # 6-7 p. 518 - 527
反应条件
1: sodium hydride / N,N-dimethyl-acetamide 2: benzene 3: KOH / ethanol View Scheme
参考文献
Kumar, S.T.V.S. Kiran; Sharma; Srivastava, Shipra; Bhandari, Kalpana; Shander, Girija; Singh
Medicinal Chemistry Research, 2004 , vol. 13, # 6-7 p. 518 - 527
反应条件
1: Cs2CO3 / Pd(OAc)2; rac-BINAP / toluene / 0.5 h / Heating
2: EtOH / pyridinium p-toluenesulfonate / 24 h / 70 °C
View Scheme
参考文献
Sasaki, Hirofumi; Haraguchi, Yoshikazu; Itotani, Motohiro; Kuroda, Hideaki; Hashizume, Hiroyuki; Tomishige, Tatsuo; Kawasaki, Masanori; Matsumoto, Makoto; Komatsu, Makoto; Tsubouchi, Hidetsugu
Journal of Medicinal Chemistry, 2006 , vol. 49, # 26 p. 7854 - 7860
