1-(4-氯苯基)-1-氰基环丁烷合成路线 （共 17 条）
反应条件
sodium hydride in tetrahydrofuran T=0 - 20°C; 12 h;
参考文献
REVIVA PHARMAMEUTICALS, INC.
Patent: WO2008/34142 A2, 2008 ;
Location in patent: Page/Page column 43-44 ;
反应条件
hydrogenchloride; sodium borohydride in methanol; diethylene glycol dimethyl ether; water; toluene
参考文献
The Boots Company plc
Patent: US4522828 A1, 1985 ;
反应条件
potassium hexamethylsilazane in tetrahydrofuran
参考文献
Krishnamurthy, Dhileepkumar; Han, Zhengxu; Wald, Stephen A.; Senanayake, Chris H.
Tetrahedron Letters, 2002 , vol. 43, # 13 p. 2331 - 2333
反应条件
potassium hydroxide in diethyl ether; dimethyl sulfoxide T=20 - 25°C; 1.5 h;
参考文献
Reddy, G. Om; Sarma; Chandrasekhar; Babu, J. Moses; Prasad; Raju, C.M. Haricharan
Organic Process Research and Development, 1999 , vol. 3, # 6 p. 488 - 492
反应条件
diisobutylaluminium hydride
参考文献
Boots Company, PLC
Patent: US4925879 A1, 1990 ;
反应条件
potassium hydroxide in diethylene glycol
参考文献
Hill, E. Alexander; Li, Baoju
Journal of Organometallic Chemistry, 1993 , vol. 448, # 1-2 p. 9 - 14
反应条件
in (2S)-N-methyl-1-phenylpropan-2-amine hydrate; ethylene glycol
参考文献
Commonwealth Scientific and Industrial Research Organization
Patent: US4235926 A1, 1980 ;
反应条件
1: in toluene T=90°C; 18 h; Inert atmosphere; 2: With hydrogenchloride; water T=90 - 95°C;
参考文献
Reddy, G. Om; Sarma; Chandrasekhar; Babu, J. Moses; Prasad; Raju, C.M. Haricharan
Organic Process Research and Development, 1999 , vol. 3, # 6 p. 488 - 492
反应条件
1: in tetrahydrofuran; toluene T=105°C; 3 h; 2: With hydrogenchloride; water in methanol T=20°C; pH=< 1; 2 h;
参考文献
Han, Zhengxu; Krishnamurthy, Dhileepkumar; Senanayake, Chris H.
Organic Process Research and Development, 2006 , vol. 10, # 2 p. 327 - 333
反应条件
Yield given. Multistep reaction;
参考文献
Jeffery, James E.; Kerrigan, Frank; Miller, Thomas K.; Smith, Graham J.; Tometzki, Gerald B.
Journal of the Chemical Society - Perkin Transactions 1, 1996 , # 21 p. 2583 - 2589
