1-(2-氟苯基)环丁烷甲腈合成路线 （共 4 条）
反应条件
sodium hydride in diethyl ether; dimethyl sulfoxide T=20 - 30°C;
参考文献
AbbVie Inc.; Bayburt, Erol K.; Clapham, Bruce; Cox, Phil B.; Daanen, Jerome F.; Gomtsyan, Arthur; Kort, Michael E.; Kym, Philip R.; Voight, Eric A.
Patent: US2013/150409 A1, 2013 ;
Location in patent: Paragraph 0253 ;
反应条件
1: (2-fluorophenyl)acetonitrile With sodium hydride in dimethyl sulfoxide T=20°C; 0.5 h; 2: 3-chloropropyl chloride in dimethyl sulfoxide T=75°C; 5 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2005/66126 A1, 2005 ;
Location in patent: Page/Page column 43 ;
WO 2005/066126 A1
反应条件
potassium hydroxide in ethylene glycol
T=198°C; 3 h; Heating / reflux;
参考文献
Merck and Co., Inc.
Patent: WO2003/104207 A2, 2003 ;
Location in patent: Page 41 ;
反应条件
1: With lithium aluminium tetrahydride in ethylene glycol dimethyl ether
Heating / reflux;
2: With water; Sodium potassium tartrate
T=20°C; 1 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2005/66126 A1, 2005 ;
Location in patent: Page/Page column 44-45 ;
WO 2005/066126 A1
