2-氯-6-三氟甲基烟酸合成路线 (共 12 条)
反应条件
1: borane-THF
2: thionyl chloride / dichloromethane
View Scheme
参考文献
Yang, Yifan; Miller, Keith J.; Zhu, Yeheng; Hong, Yang; Tian, Yuan; Murugesan, Natesan; Gu, Zhengxiang; O'Tanyi, Eva; Keim, William J.; Rohrbach, Kenneth W.; Johnghar, Susan; Behnia, Kamelia; Pelleymounter, Mary Ann; Carlson, Kenneth E.; Ewing, William R.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 22 p. 6856 - 6860
反应条件
1: borane-THF / tetrahydrofuran / 16 h / 20 °C
2: pyridinium chlorochromate; silica gel / dichloromethane / 4 h / 20 °C
View Scheme
参考文献
BAYER INTELLECTUAL PROPERTY GMBH; GREUL, Jörg, Nico; MANSFIELD, Darren; FÜSSLEIN, Martin; RIECK, Heiko; RIEDRICH, Matthias; RODEFELD, Lars; KATHER, Kristian; MALSAM, Olga; LÖSEL, Peter; VOERSTE, Arnd; SCHWARZ, Hans-Georg; ILG, Kerstin; GÖRGENS, Ulrich; CARLES, Lionel; COQUERON, Pierrre-Yves; DESBORDES, Philippe; MERESSE, Philippe
Patent: WO2013/64460 A1, 2013 ;