1-环状己烯三氟甲烷磺酸合成路线 （共 56 条）
反应条件
1: NEt3 / Pd(PPh3)2Cl2 2: 16 percent / SeO2 / benzene / 52 h / 80 °C View Scheme
参考文献
No, Zaesung; Chae, Yung Bog; Shin, Chan Jae; Chung, Yongseog
Tetrahedron Letters, 1998 , vol. 39, # 34 p. 6191 - 6194
反应条件
1: 82 percent / K2CO3 / (Ph3P)2PdCl2 / tetrahydrofuran; H2O / 0.5 h / 25 °C
2: 90 percent / Amberlyst 15 / CHCl3 / 15 h / 25 °C
3: 85 percent / TFA / 6 h / 20 °C
View Scheme
参考文献
Occhiato, Ernesto G.; Prandi, Cristina; Ferrali, Alessandro; Guarna, Antonio; Venturello, Paolo
Journal of Organic Chemistry, 2003 , vol. 68, # 25 p. 9728 - 9741
反应条件
1: With trifuran-2-yl-phosphane; tetra-(n-butyl)ammonium iodide; tris-(dibenzylideneacetone)dipalladium(0) in 1-methyl-pyrrolidin-2-one
T=20°C; Negishi Coupling Reaction;
2: With ammonium chloride in 1-methyl-pyrrolidin-2-one; water
参考文献
ACADIA PHARMACEUTICALS INC.
Patent: WO2008/33894 A2, 2008 ;
Location in patent: Page/Page column 53-54 ;
WO 2008/033894 A2
反应条件
tetra-(n-butyl)ammonium iodide; tris-(dibenzylideneacetone)dipalladium(0); trifuran-2-yl-phosphane in 1-methyl-pyrrolidin-2-one
T=20°C; Negishi Coupling Reaction;
参考文献
Olsson, Roger; Hyldtoft, Lene; Piu, Fabrice; Gustafsson, Magnus
Patent: US2005/256210 A1, 2005 ;
Location in patent: Page/Page column 45 ;
US 20050256210 A1
反应条件
copper(l) iodide; diethylamine; bis-triphenylphosphine-palladium(II) chloride in tetrahydrofuran
Sonogashira coupling; 16 h; Heating;
参考文献
Tessier, Pierre E.; Nguyen, Natalie; Clay, Matthew D.; Fallis, Alex G.
Organic Letters, 2005 , vol. 7, # 5 p. 767 - 770
反应条件
1: cyclohexylMgCl With zinc(II) chloride in tetrahydrofuran
T=20°C;
2: carbon monoxide; cyclohex-1-en-1-yl trifluoromethanesulfonate With magnesium bromide; nickel dichloride in tetrahydrofuran; dimethyl sulfoxide
T=80°C; Negishi coupling; P=760.051 Torr; 0.333333 h; Further stages.;
参考文献
Wang, Qiaoling; Chen, Chuo
Tetrahedron Letters, 2008 , vol. 49, # 18 p. 2916 - 2921
反应条件
sodium carbonate; tetrakis(triphenylphosphine) palladium(0) in diethyl ether; water
T=20°C; 4 h;
参考文献
ACADIA PHARMACEUTICALS INC.
Patent: WO2008/33894 A2, 2008 ;
Location in patent: Page/Page column 73-74 ;
WO 2008/033894 A2
反应条件
pyridine; hydrogen; palladium diacetate; di-(1-adamantyl)-n-butylphosphine in N,N-dimethyl-formamide
T=80°C; P=15001.5 Torr; 16 h;
参考文献
Neumann, Helfried; Sergeev, Alexey; Beller, Matthias
Angewandte Chemie - International Edition, 2008 , vol. 47, # 26 p. 4887 - 4891
反应条件
Co(acetylacetonate)3 in tetrahydrofuran
T=20°C; 12 h; Inert atmosphere;
参考文献
Alford, Joshua S.; Spangler, Jillian E.; Davies, Huw M.L.
Journal of the American Chemical Society, 2013 , vol. 135, # 32 p. 11712 - 11715
反应条件
1,3,5,7-tetra-azatricyclo[5.1.1.13,5]decane; dnpf; bis(dibenzylideneacetone)-palladium(0) in tetrahydrofuran
T=80°C; Heck Reaction; 24 h; Inert atmosphere;
参考文献
Zou, Yinjun; Qin, Liena; Ren, Xinfeng; Lu, Yunpeng; Li, Yongxin; Zhou, Jianrong
Chemistry - A European Journal, 2013 , vol. 19, # 10 p. 3504 - 3511
