1-甲基-1,2,5,6-四氢烟酸乙酯合成路线 （共 9 条）
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in dimethyl sulfoxide T=120°C; 0.75 h;
参考文献
Kurihara, Takushi; Matsubara, Yoshitaka; Osaki, Hirotaka; Harusawa, Shinya; Yoneda, Ryuji
Heterocycles, 1990 , vol. 30, # 2 p. 885 - 896
反应条件
acetic acid T=80°C; 22 h;
参考文献
Baenziger, Markus; Klein, Solange; Rihs, Grety
Helvetica Chimica Acta, 2002 , vol. 85, # 5 p. 1399 - 1406
反应条件
1: 42.09 g / AcOH; H2 / Pd/C / ethanol / 20 °C 2: 52 percent / (iPr)2NH; BuLi / tetrahydrofuran 3: 6.7 g / oxone / acetone; H2O / 0.5 h / 0 - 5 °C 4: DBU / toluene / 1 h / 110 °C View Scheme
参考文献
Baenziger, Markus; Klein, Solange; Rihs, Grety
Helvetica Chimica Acta, 2002 , vol. 85, # 5 p. 1399 - 1406
反应条件
sodium tetrahydroborate in methanol 6 h; Ambient temperature; Yield given;
参考文献
Moos; Bergmeier; Coughenour; Davis; Hershenson; Kester; McKee; Marriott; Schwarz; Tecle; Thomas
Journal of Pharmaceutical Sciences, 1992 , vol. 81, # 10 p. 1015 - 1019
反应条件
1: 52 percent / (iPr)2NH; BuLi / tetrahydrofuran 2: 6.7 g / oxone / acetone; H2O / 0.5 h / 0 - 5 °C 3: DBU / toluene / 1 h / 110 °C View Scheme
参考文献
Baenziger, Markus; Klein, Solange; Rihs, Grety
Helvetica Chimica Acta, 2002 , vol. 85, # 5 p. 1399 - 1406
反应条件
1: 6.7 g / oxone / acetone; H2O / 0.5 h / 0 - 5 °C 2: DBU / toluene / 1 h / 110 °C View Scheme
参考文献
Baenziger, Markus; Klein, Solange; Rihs, Grety
Helvetica Chimica Acta, 2002 , vol. 85, # 5 p. 1399 - 1406
参考文献
Jahns
Archiv der Pharmazie (Weinheim, Germany), 1891 , vol. 229, p. 691
参考文献
Tsukamoto; Komori
Yakugaku Zasshi, 1953 , vol. 73, p. 779
Chem.Abstr., 1954 , p. 7021
参考文献
Nopco Chem. Co.
Patent: US2569182 , 1949 ;
