(2-甲氧基苯基)(4-甲基苯基)甲酮合成路线 （共 13 条）
反应条件
1: With AlCl3, aluminium chloride
T=0 - 20°C; Friedel-Crafts Acylation;
2: With water in toluene
参考文献
GENFIT
Patent: US2010/4159 A1, 2010 ;
Location in patent: Page/Page column 51-52 ;
反应条件
(3aS,7aS)-1,3-di-o-tolyl-octahydro-benzoimidazole-2-thione; palladium diacetate in tetrahydrofuran
T=50°C; Suzuki reaction; 10 h;
参考文献
Mingji, Dai; Liang, Bo; Wang, Cuihua; You, Zejin; Xiang, Jing; Dong, Guangbin; Chen, Jiahua; Yang, Zhen
Advanced Synthesis and Catalysis, 2004 , vol. 346, # 13-15 p. 1669 - 1673
反应条件
palladium diacetate; potassium carbonate in ethylene glycol dimethyl ether
T=20°C; carbonylative coupling; P=760 Torr; 2 h;
参考文献
Xia, Min; Chen, Zhenchu
Journal of Chemical Research - Part S, 1999 , # 6 p. 400 - 401
反应条件
dichloro bis(acetonitrile) palladium(II) in tetrahydrofuran
T=55°C; 16 h;
参考文献
Fausett, Bryan W.; Liebeskind, Lanny S.
Journal of Organic Chemistry, 2005 , vol. 70, # 12 p. 4851 - 4853
反应条件
carbonylchlorohydridetris(triphenylphosphine) ruthenium(II); water; potassium carbonate in toluene
T=110°C; 13 h; Inert atmosphereSealed tube;
参考文献
Fukuyama, Takahide; Okamoto, Hiromi; Ryu, Ilhyong
Chemistry Letters, 2011 , vol. 40, # 12 p. 1453 - 1455
反应条件
1: 2-methoxybromobenzene With magnesium in tetrahydrofuran
Heating;
2: 4-methyl-benzaldehyde in tetrahydrofuran
T=0 - 20°C; 3 h;
3: With dipyridinium dichromate; 4 A molecular sieve in dichloromethane
T=20°C; 2 h; Further stages.;
参考文献
Chittimalla, Santhosh Kumar; Chang, Tsung-Che; Liu, Ting-Chun; Hsieh, Hsing-Pang; Liao, Chun-Chen
Tetrahedron, 2008 , vol. 64, # 11 p. 2586 - 2595
反应条件
1: Lewis acid / nitrobenzene / Heating
View Scheme
参考文献
Goethals, G.; Nadio, L.; Uzan, R.
Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy, 1981 , vol. 37, # 3 p. 199 - 204
反应条件
1: With trifluoroacetic anhydride
T=80°C;
2: With boron trifluoride diethyl etherate
T=80°C; Friedel-Crafts reaction; Title compound not separated from byproducts;
参考文献
Wilkinson, Mark C.; Saez, Fabienne; Wei, Lee Hon
Synlett, 2006 , # 7 p. 1063 - 1066
反应条件
trifluoroacetic acid
5 h; Heating;
参考文献
Keumi, Takashi; Morita, Toshio; Shimada, Takanobu; Teshima, Naomi; Kitajima, Hidehiko; Prakash, G. K. Surya
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1986 , p. 847 - 852
反应条件
C4F9SO3H
T=155°C; 1 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Effenberger, Franz; Sohn, Erich; Epple, Gerhard
Chemische Berichte, 1983 , vol. 116, # 3 p. 1195 - 1208
