1-苯基-1-氨基甲基乙烯合成路线 （共 12 条）
反应条件
ammonia in methanol
T=130°C; 16 h;
参考文献
Van Hende, Eva; Verniest, Guido; Deroose, Frederik; Thuring, Jan-Willem; Macdonald, Gregor; De Kimpe, Norbert
Journal of Organic Chemistry, 2009 , vol. 74, # 5 p. 2250 - 2253
反应条件
1: With hydrazine in ethanol
1 h; Reflux;
2: With hydrogenchloride in ethanol; water
1 h; Reflux;
参考文献
Fort, Diego A.; Woltering, Thomas J.; Nettekoven, Matthias; Knust, Henner; Bach, Thorsten
Chemical Communications, 2013 , vol. 49, # 29 p. 2989 - 2991
反应条件
triethyl phosphite; copper(I) bromide
T=85°C;
参考文献
Kalita, Biswajit; Nicholas, Kenneth M.
Tetrahedron Letters, 2005 , vol. 46, # 9 p. 1451 - 1453
反应条件
1: NaH / diethyl ether / 0 °C
2: xylene / Heating
3: 6M NaOH
View Scheme
参考文献
Bujard; Briot; Gouverneur; Mioskowski
Tetrahedron Letters, 1999 , vol. 40, # 50 p. 8785 - 8788
反应条件
1: 1,2-dichloro-ethane / 80 °C / Heating
2: sodium hydroxide, 5percent triethyl benzyl ammonium chloride / 1,2-dichloro-ethane
View Scheme
参考文献
Deleris; Dunogues; Gadras
Tetrahedron, 1988 , vol. 44, # 13 p. 4243 - 4258
反应条件
sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride in 1,2-dichloro-ethane
Yield given. Yields of byproduct given;
参考文献
Deleris; Dunogues; Gadras
Tetrahedron, 1988 , vol. 44, # 13 p. 4243 - 4258
反应条件
1.1: N-bromosuccinmide / tetrachloromethane / 6 h / |Reflux
1.2: 18 h / 20 °C
2.1: hydrazine hydrate / ethanol / 1 h / |Reflux
2.2: 1 h
View Scheme
参考文献
Fort, Diego A.; Woltering, Thomas J.; Nettekoven, Matthias; Knust, Henner; Bach, Thorsten
Chemical Communications, 2013 , vol. 49, # 29 p. 2989 - 2991
反应条件
1.1: magnesium / diethyl ether / 2 h / 0 °C / |Reflux
1.2: 0.5 h / 20 °C
1.3: 24 h / |Reflux
2.1: triphenylphosphine / dichloromethane / 0.17 h / 0 °C
2.2: 3 h / 0 °C
3.1: sodium azide / tetrahydrofuran; water / 20 °C
4.1: triphenylphosphine / tetrahydrofuran; water / 8 h / 20 °C
View Scheme
参考文献
Garzan, Atefeh; Jaganathan, Arvind; Salehi Marzijarani, Nastaran; Yousefi, Roozbeh; Whitehead, Daniel C.; Jackson, James E.; Borhan, Babak
Chemistry - A European Journal, 2013 , vol. 19, # 27 p. 9015 - 9021
反应条件
sodium hydroxide
Hydrolysis;
参考文献
Bujard; Briot; Gouverneur; Mioskowski
Tetrahedron Letters, 1999 , vol. 40, # 50 p. 8785 - 8788
参考文献
Tiffeneau; Cahnmann
Bulletin de la Societe Chimique de France, 1935 , vol. <5> 2, p. 1876,1881, 1882
