3-[3,4-(亚甲二氧基)苯基]丙酸合成路线 （共 39 条）
反应条件
hydrogen; palladium on activated charcoal in N,N-dimethyl-formamide P=760 Torr; 24 h;
参考文献
Charlton, James L.; Chee, Gaik-Lean
Canadian Journal of Chemistry, 1997 , vol. 75, # 8 p. 1076 - 1083
反应条件
10 Pd/C; hydrogen in methanol T=20°C; P=760.051 Torr; 24 h;
参考文献
Jia, Yaoling; Zhou, Pengfei; Wang, Yang; Dong, Xiaoyi; Liu, Xinhua; Pan, Lilong; Xin, Hong; Zhu, Yi Zhun
European Journal of Medicinal Chemistry, 2012 , vol. 55, p. 176 - 187,12
反应条件
sodium hydroxide in water T=20°C; 2 h;
参考文献
Kalypsys, Inc.
Patent: US2006/116515 A1, 2006 ;
Location in patent: Page/Page column 58 ;
US 20060116515 A1
反应条件
jones reagent in acetone T=0°C; 1 h;
参考文献
Lima, Patricia C.; Lima, Lidia M.; Da Silva, Kelli Cristine M.; Leda, Paulo Henrique O.; De Miranda, Ana Luisa P.; Fraga, Carlos A. M.; Barreiro, Eliezer J.
European Journal of Medicinal Chemistry, 2000 , vol. 35, # 2 p. 187 - 203
反应条件
1.1: BH3*THF / tetrahydrofuran / 2 h / 20 °C 1.2: 78 percent / 30 percent H2O2; aq. NaOH / tetrahydrofuran; methanol / 4 h / 60 °C 2.1: 92 percent / Jones reagent / acetone / 1 h / 0 °C View Scheme
参考文献
Barreiro, Eliazer J.; Costa, Paulo R. R.; Coelho, Fernando A. S.; Farias, Florence M. C. de
Journal of Chemical Research, Miniprint, 1985 , # 7 p. 2301 - 2332
反应条件
1: acetic anhydride / 6 h / 20 °C 2: 10 Pd/C; hydrogen / methanol / 24 h / 20 °C / 760.05 Torr View Scheme
参考文献
Jia, Yaoling; Zhou, Pengfei; Wang, Yang; Dong, Xiaoyi; Liu, Xinhua; Pan, Lilong; Xin, Hong; Zhu, Yi Zhun
European Journal of Medicinal Chemistry, 2012 , vol. 55, p. 176 - 187,12
反应条件
1: acetic anhydride; sodium acetate / 120 °C 2: hydrogenchloride / water / 100 °C 3: acetic anhydride / 6 h / 20 °C 4: 10 Pd/C; hydrogen / methanol / 24 h / 20 °C / 760.05 Torr View Scheme
参考文献
Jia, Yaoling; Zhou, Pengfei; Wang, Yang; Dong, Xiaoyi; Liu, Xinhua; Pan, Lilong; Xin, Hong; Zhu, Yi Zhun
European Journal of Medicinal Chemistry, 2012 , vol. 55, p. 176 - 187,12
反应条件
1: hydrogenchloride / water / 100 °C 2: acetic anhydride / 6 h / 20 °C 3: 10 Pd/C; hydrogen / methanol / 24 h / 20 °C / 760.05 Torr View Scheme
参考文献
Jia, Yaoling; Zhou, Pengfei; Wang, Yang; Dong, Xiaoyi; Liu, Xinhua; Pan, Lilong; Xin, Hong; Zhu, Yi Zhun
European Journal of Medicinal Chemistry, 2012 , vol. 55, p. 176 - 187,12
反应条件
1: 81.9 percent / pyridine; piperidine / 8 h / Heating 2: 91.1 percent / hydrogen; acetic acid / Pd-C / 48 h / Heating View Scheme
参考文献
Barreiro, Eliazer J.; Costa, Paulo R. R.; Coelho, Fernando A. S.; Farias, Florence M. C. de
Journal of Chemical Research, Miniprint, 1985 , # 7 p. 2301 - 2332
反应条件
T=100°C; unter Druck;
参考文献
Kaufmann; Radosevic
Chemische Berichte, 1916 , vol. 49, p. 680,682
