5-溴-2,3-二氢苯并[B]呋喃-7-甲醛合成路线 （共 6 条）
反应条件
1,3,5,7-tetra-azatricyclo[5.1.1.13,5]decane in trifluoroacetic acid T=50°C;
参考文献
Eisai Co., Ltd.
Patent: EP1394147 A1, 2004 ;
Location in patent: Page 92 ;
反应条件
1: 5,7-Dibromo-2,3-dihydrobenzofuran With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.333333 h; 2: N,N-dimethyl-formamide in tetrahydrofuran; hexane T=-78 - 20°C; 3.33333 h;
参考文献
NOVO NORDISK A/S
Patent: WO2006/82245 A1, 2006 ;
Location in patent: Page/Page column 181-182 ;
反应条件
1: 5,7-Dibromo-2,3-dihydrobenzofuran With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.333333 h; 2: N,N-dimethyl-formamide in tetrahydrofuran; hexane T=-78 - 20°C; 3 h;
参考文献
NOVO NORDISK A/S
Patent: WO2006/5683 A1, 2006 ;
Location in patent: Page/Page column 176-177 ;
反应条件
n-butyllithium; ammonium chloride in tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide
参考文献
Hunter, Duncan H.; Janabi, Mustafa
Patent: US2002/182169 A1, 2002 ;
反应条件
1: 2-(2.4.6-Tribromphenoxy)ethylchlorid With n-butyllithium in tetrahydrofuran T=-40°C; Metallation; 2: N,N-dimethyl-formamide in tetrahydrofuran T=-40 - 20°C; Formylation; Parham cyclization;
参考文献
Plotkin, Michael; Chen, Sanyou; Spoors, P. Grant
Tetrahedron Letters, 2000 , vol. 41, # 14 p. 2269 - 2273
反应条件
1.1: K2CO3 / dimethylformamide 2.1: n-BiLu / tetrahydrofuran / -40 °C 2.2: 36 percent / tetrahydrofuran / -40 - 20 °C View Scheme
参考文献
Plotkin, Michael; Chen, Sanyou; Spoors, P. Grant
Tetrahedron Letters, 2000 , vol. 41, # 14 p. 2269 - 2273
