2-羟基-3-硝基苯乙酮合成路线 （共 15 条）
反应条件
1: 77 percent / NaOEt / ethanol / 0.33 h / Heating 2: 80 percent / H2SO4 / 0.08 h / 60 °C 3: 85 percent / SnCl2*2H2O, 2N HCl / ethanol / Heating View Scheme
参考文献
Funke, Mario; Thimm, Dominik; Schiedel, Anke C.; Mueller, Christa E.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 12 p. 5182 - 5197
反应条件
1.1: potassium tert-butylate / N,N-dimethyl-formamide / 0 - 5 °C / |Inert atmosphere 1.2: |Inert atmosphere 2.1: hydrogenchloride / ethanol; water / |Inert atmosphere; |Reflux 3.1: SnCl2·2H2O; hydrogenchloride / ethanol; water / 65 - 70 °C 4.1: potassium carbonate / ethanol; water; tetrahydrofuran / 20 °C 4.2: pH <= 2 View Scheme
参考文献
Funke, Mario; Thimm, Dominik; Schiedel, Anke C.; Mueller, Christa E.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 12 p. 5182 - 5197
反应条件
hydrogenchloride; tin(ll) chloride
参考文献
Solvay Pharmaceuticalss GmbH
Patent: US2007/117823 A1, 2007 ;
Location in patent: Page/Page column 7 ;
反应条件
1: 77 percent / NaOEt / ethanol / 0.33 h / Heating
2: 80 percent / H2SO4 / 0.08 h / 60 °C
View Scheme
参考文献
Funke, Mario; Thimm, Dominik; Schiedel, Anke C.; Mueller, Christa E.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 12 p. 5182 - 5197
反应条件
oxalyl dichloride
T=0 - 20°C; Vilsmeier reaction;
参考文献
China Raju; Nageswara Rao; Suman; Yogeeswari; Sriram; Shaik, Thokhir Basha; Kalivendi, Shasi Vardhan
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 10 p. 2855 - 2859
