3-(2-氧代-1-苯基环己基)丙酸合成路线 （共 4 条）
反应条件
hydrogenchloride; water; acetic acid T=20°C; 16 h; RefluxInert atmosphere;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; DAS, Jagabandhu; KO, Soo Sung
Patent: WO2012/40532 A1, 2012 ;
Location in patent: Page/Page column 36-37 ;
WO 2012/040532 A1
反应条件
1: 1,4-dioxane; triton B surfactant / 3 h / 20 °C 2: hydrogenchloride; water; acetic acid / 16 h / 20 °C / Reflux; Inert atmosphere View Scheme
参考文献
BRISTOL-MYERS SQUIBB COMPANY; DAS, Jagabandhu; KO, Soo Sung
Patent: WO2012/40532 A1, 2012 ;
WO 2012/040532 A1
反应条件
hydrogenchloride 8 h; Heating;
参考文献
Fischer, Friedrich; Palitzsch, Peter
Zeitschrift fuer Chemie (Stuttgart, Germany), 1982 , vol. 22, # 8 p. 309 - 310
反应条件
1: With hydrazine hydrate; potassium hydroxide in ethylene glycol
T=130°C; 3.5 h; Reflux;
2: With hydrogenchloride in water; ethylene glycol
T=20°C;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; DAS, Jagabandhu; KO, Soo Sung
Patent: WO2012/40532 A1, 2012 ;
Location in patent: Page/Page column 37 ;
WO 2012/040532 A1
