四氢-6-甲氧基-2H-吡喃-3-醇合成路线 （共 11 条）
反应条件
1: 69 percent / pyridine; 4-dimethylaminopyridine / CH2Cl2 / 15 h / 23 °C
2: 76 percent / aq. acetic acid / 48 h / 90 °C
View Scheme
参考文献
Ayala, Leticia; Lucero, Claudia G.; Antoinette, Jan; Romero; Tabacco, Sarah A.; Woerpel
Journal of the American Chemical Society, 2003 , vol. 125, # 50 p. 15521 - 15528
反应条件
1: 69 percent / pyridine; 4-dimethylaminopyridine / CH2Cl2 / 15 h / 23 °C
2: 76 percent / aq. acetic acid / 48 h / 90 °C
3: 80 percent / pyridine; 4-dimethylaminopyridine / CH2Cl2 / 38 h
View Scheme
参考文献
Ayala, Leticia; Lucero, Claudia G.; Antoinette, Jan; Romero; Tabacco, Sarah A.; Woerpel
Journal of the American Chemical Society, 2003 , vol. 125, # 50 p. 15521 - 15528
反应条件
1: 93 percent / triethylamine / CH2Cl2 / 3 h / 0 °C
2: 95 percent / sodium azide / dimethylformamide / 48 h / 80 °C
3: 95 percent / aq. HCl / tetrahydrofuran / 24 h
View Scheme
参考文献
Ayala, Leticia; Lucero, Claudia G.; Antoinette, Jan; Romero; Tabacco, Sarah A.; Woerpel
Journal of the American Chemical Society, 2003 , vol. 125, # 50 p. 15521 - 15528
反应条件
1: zinc bromide; diethyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 24 h / 23 °C
2: 2.67 g / aq. HCl / tetrahydrofuran / 36 h
3: 73 percent / pyridine; 4-dimethylaminopyridine / CH2Cl2 / 24 h
View Scheme
参考文献
Ayala, Leticia; Lucero, Claudia G.; Antoinette, Jan; Romero; Tabacco, Sarah A.; Woerpel
Journal of the American Chemical Society, 2003 , vol. 125, # 50 p. 15521 - 15528
反应条件
triphenylphosphine; zinc(II) iodide; diethylazodicarboxylate in tetrahydrofuran
T=25°C; Mitsunobu reaction; 12 h;
参考文献
Ayala, Leticia; Lucero, Claudia G.; Antoinette, Jan; Romero; Tabacco, Sarah A.; Woerpel
Journal of the American Chemical Society, 2003 , vol. 125, # 50 p. 15521 - 15528
反应条件
1: 41 percent / zinc iodide; diethyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 12 h / 25 °C
2: 45 percent / aq. HCl / tetrahydrofuran / 12 h / 55 °C
3: 84 percent / pyridine; 4-dimethylaminopyridine / CH2Cl2 / 12 h
View Scheme
参考文献
Ayala, Leticia; Lucero, Claudia G.; Antoinette, Jan; Romero; Tabacco, Sarah A.; Woerpel
Journal of the American Chemical Society, 2003 , vol. 125, # 50 p. 15521 - 15528
反应条件
pyridine; 4-(N,N-dimethlyamino)pyridine in dichloromethane
T=23°C; 15 h;
参考文献
Ayala, Leticia; Lucero, Claudia G.; Antoinette, Jan; Romero; Tabacco, Sarah A.; Woerpel
Journal of the American Chemical Society, 2003 , vol. 125, # 50 p. 15521 - 15528
反应条件
1: 93 percent / triethylamine / CH2Cl2 / 3 h / 0 °C
2: 95 percent / sodium azide / dimethylformamide / 48 h / 80 °C
View Scheme
参考文献
Ayala, Leticia; Lucero, Claudia G.; Antoinette, Jan; Romero; Tabacco, Sarah A.; Woerpel
Journal of the American Chemical Society, 2003 , vol. 125, # 50 p. 15521 - 15528
反应条件
1: zinc bromide; diethyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 24 h / 23 °C
2: 2.67 g / aq. HCl / tetrahydrofuran / 36 h
View Scheme
参考文献
Ayala, Leticia; Lucero, Claudia G.; Antoinette, Jan; Romero; Tabacco, Sarah A.; Woerpel
Journal of the American Chemical Society, 2003 , vol. 125, # 50 p. 15521 - 15528
反应条件
1: 41 percent / zinc iodide; diethyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 12 h / 25 °C
2: 45 percent / aq. HCl / tetrahydrofuran / 12 h / 55 °C
View Scheme
参考文献
Ayala, Leticia; Lucero, Claudia G.; Antoinette, Jan; Romero; Tabacco, Sarah A.; Woerpel
Journal of the American Chemical Society, 2003 , vol. 125, # 50 p. 15521 - 15528
