4,4-二甲氧基四氢-4H-吡喃合成路线 （共 9 条）
反应条件
toluene sulfonic acid in methanol T=80°C; 0.5 h; Sealed tube;
参考文献
NOVARTIS AG; ANTONIOS-MCCREA, William, R.; BARSANTI, Paul, A.; HU, Cheng; JIN, Xianming; MARTIN, Eric, J.; PAN, Yue; PFISTER, Keith, B.; SENDZIK, Martin; SUTTON, James; WAN, Lifeng
Patent: WO2012/66070 A1, 2012 ;
Location in patent: Page/Page column 91-92 ;
WO 2012/066070 A1
反应条件
toluene-4-sulfonic acid in methanol T=80°C; 0.5 h;
参考文献
NOVARTIS AG; PFISTER, Keith B; SENDZIK, Martin
Patent: WO2011/26917 A1, 2011 ;
Location in patent: Page/Page column 66 ;
WO 2011/026917 A1
反应条件
titanium tetrachloride; triethylamine in dichloromethane T=20°C; 0.75 h;
参考文献
Clerici, Angelo; Pastori, Nadia; Porta, Ombretta
Tetrahedron, 2001 , vol. 57, # 1 p. 217 - 225
反应条件
toluene-4-sulfonic acid in methanol
参考文献
Bird; Olivier
Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 5 p. 515 - 520
反应条件
titanium tetrachloride; triethylamine T=20°C; 10 h;
参考文献
ABBOTT LABORATORIES; ABBOTT LABORATORIES TRADING (SHANGHAI) COMPANY, LTD.; WANG, Xueqing; MEYER, Michael; YAO, Betty; GUO, Tao; WEI, Guo Ping,Robert; WANG, Lijuan, Jane
Patent: WO2013/10453 A1, 2013 ;
Location in patent: Page/Page column 153 ;
反应条件
1.1: pyridine; titanium tetrachloride / dichloromethane / 1 h 1.2: 1 h / 100 °C 2.1: 1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo-[2.2.2]octane bis(tetrafluoroborate) / water; acetonitrile / 20 °C View Scheme
参考文献
ABBOTT LABORATORIES; ABBOTT LABORATORIES TRADING (SHANGHAI) COMPANY, LTD.; WANG, Xueqing; MEYER, Michael; YAO, Betty; GUO, Tao; WEI, Guo Ping,Robert; WANG, Lijuan, Jane
Patent: WO2013/10453 A1, 2013 ;
反应条件
titanium tetrachloride in dichloromethane T=-78 - 20°C; Inert atmosphere;
参考文献
Kyowa Hakko Kirin Co., Ltd.
Patent: EP2090570 A1, 2009 ;
Location in patent: Page/Page column 95 ;
EP 2090570 A1
反应条件
1: 62 percent / TiCl4 2: 73 percent View Scheme
参考文献
Bird; Olivier
Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 5 p. 515 - 520
反应条件
1: With titanium tetrachloride in dichloromethane T=-78°C; 1 h; 2: With pyridine; potassium hydroxide in dichloromethane T=-78 - 20°C; 1.33333 h; Further stages.;
参考文献
ABBOTT LABORATORIES; ABBOTT LABORATORIES TRADING (SHANGHAI) COMPANY, LTD.; WANG, Xueqing; MEYER, Michael; YAO, Betty; GUO, Tao; WEI, Guo Ping,Robert; WANG, Lijuan, Jane
Patent: WO2013/10453 A1, 2013 ;
Location in patent: Page/Page column 223 ;
