6-硝基-3,4-二氢-2H-1,4-苯并噁嗪合成路线 （共 14 条）
反应条件
borane-THF in tetrahydrofuran 0.666667 h;
参考文献
Szczepankiewicz, Bruce G.; Heathcock, Clayton H.
Tetrahedron, 1997 , vol. 53, # 26 p. 8853 - 8870
反应条件
potassium carbonate in N,N-dimethyl-formamide T=125°C; Inert atmosphere;
参考文献
SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH; CHIOSIS, Gabriela; TALDONE, Tony; SUN, Weilin
Patent: WO2011/44394 A1, 2011 ;
Location in patent: Page/Page column 117-118 ;
反应条件
sodium carbonate in water T=2 - 18°C; 2 h; Irradiation;
参考文献
Wubbels, Gene G.; Halverson, Ann M.; Oxman, Joe D.
Journal of the American Chemical Society, 1980 , vol. 102, # 14 p. 4848 - 4849
反应条件
hydrogenchloride T=100°C; 2.5 h;
参考文献
Foeldenyi; Szalontai; Szebenyi; Kvintovics; Bartik
Monatshefte fur Chemie, 1996 , vol. 127, # 3 p. 305 - 311
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
反应条件
1: 94 percent / HCOONa / 2.5 h / Heating 2: 42 percent / NaH / dimethylformamide / 1.) 20 deg C, 4 h, 2.) 120-140 deg C, 20 h 3: 78 percent / 1 N aq. HCl / 2.5 h / 100 °C View Scheme
参考文献
Petter, Russell C.; Jewell, Charles F.; Lee, Kwangho; Medikonda, Aravind Prasad; Niu, Deqiang; Qiao, Lixin; Singh, Juswinder; Zhu, Zhendong
Patent: US2011/269244 A1, 2011 ;
反应条件
1: 42 percent / NaH / dimethylformamide / 1.) 20 deg C, 4 h, 2.) 120-140 deg C, 20 h 2: 78 percent / 1 N aq. HCl / 2.5 h / 100 °C View Scheme
参考文献
Foeldenyi; Szalontai; Szebenyi; Kvintovics; Bartik
Monatshefte fur Chemie, 1996 , vol. 127, # 3 p. 305 - 311
反应条件
1: 4-(N,N-dimethlyamino)pyridine; n-butyllithium; dicyclohexyl-carbodiimide / dichloromethane; ethyl acetate; tetrahydrofuran 2: boron trifluoride / tetrahydrofuran View Scheme
参考文献
Petter, Russell C.; Jewell, Charles F.; Lee, Kwangho; Medikonda, Aravind Prasad; Niu, Deqiang; Qiao, Lixin; Singh, Juswinder; Zhu, Zhendong
Patent: US2011/269244 A1, 2011 ;
反应条件
sodium carbonate T=0 - 18°C; 1.5 h; Irradiationother β-(nitrophenoxy)ethylamines; Product distributionMechanism;
参考文献
Wubbels, Gene G.; Halverson, Ann M.; Oxman, Joe D.; Bruyn, Van H. De
Journal of Organic Chemistry, 1985 , vol. 50, # 23 p. 4499 - 4504
反应条件
1: 3,4-dihydro-6-nitro-2H-benzo[b][1,4]oxazine With sodium hydride in N,N-dimethyl-formamide T=0°C; 0.5 h; 2: methyl iodide in N,N-dimethyl-formamide T=20°C; 2 h;
参考文献
SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH; CHIOSIS, Gabriela; TALDONE, Tony; SUN, Weilin
Patent: WO2011/44394 A1, 2011 ;
Location in patent: Page/Page column 117-118 ;
