6-硝基-3,4-二氢-2H-1,4-苯并噁嗪合成路线 （共 14 条）
反应条件
1: 88 percent / 1 h / Heating 2: 1.) 1 M BH3-THF, 2.) HCl / 1.) THF, a) reflux, 2 h, b) cool down, overnight, 2.) 0.25 h View Scheme
参考文献
Chapleo, Christopher B.; Butler, Richard C. M.; England, David C.; Myers, Peter L.; Roach, Alan G.; et al.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 7 p. 1627 - 1630
反应条件
1: 35 percent / NaBH(OAc)3; AcOH; Na2SO4
2: H2 / Pd/C / ethanol / 12 h / 760 Torr
View Scheme
参考文献
Zhang, Deyi; Kohlman, Dan; Krushinski, Joseph; Liang, Sidney; Ying, Bai-Ping; Reilly, John E.; Dinn, Sean R.; Wainscott, David B.; Nutter, Suzanne; Gough, Wendy; Nelson, David L.G.; Schaus, John M.; Xu, Yao-Chang
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 24 p. 6011 - 6016
反应条件
1.1: sodium hydrogencarbonate / dichloromethane / 0.5 h / 0 °C
1.2: 2 h / 20 °C
2.1: palladium 10 on activated carbon; hydrogen / methanol; tetrahydrofuran / 2 h / 20 °C
View Scheme
参考文献
Lee, Jeewoo; Tran, Phuong-Thao; Hoang, Van-Hai; Thorat, Shivaji A.; Kim, Sung Eun; Ann, Jihyae; Chang, Yu Jin; Nam, Dong Woo; Song, Hyundong; Mook-Jung, Inhee; Lee, Jiyoun
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 13 p. 3821 - 3830
反应条件
4-(N,N-dimethlyamino)pyridine in acetonitrile
Heating / reflux;
参考文献
Schering Corporation and Pharmacopeia Drug Discovery, Inc.
Patent: US2007/93477 A1, 2007 ;
Location in patent: Page/Page column 43 ;
