2,3,7,7a-四氢-4,7a-二甲基-1H-茚-1,5(6H)-二酮合成路线 （共 12 条）
反应条件
toluene-4-sulfonic acid in toluene
1 h; Reflux;
参考文献
BIKAM PHARMACEUTICALS, INC.; GARVEY, David, S.; LAROSA, Gregory, J.; GREENWOOD, Jeremy, R.; FRYE, Leah, L.; QUACH, Tan; COTE, Jamie, B.; BERMAN, Judd
Patent: WO2013/58809 A1, 2013 ;
Location in patent: Page/Page column 81 ;
反应条件
toluene-4-sulfonic acid in toluene
48 h; Heating;
参考文献
Banerjee, Ajoy K.; Vera, William
Recueil des Travaux Chimiques des Pays-Bas, 1995 , vol. 114, # 3 p. 87 - 90
反应条件
1: BF3*OEt2, H2O / CH2Cl2 / 1 h
2: BF3*OEt2, H2O / CH2Cl2 / 4 h
View Scheme
参考文献
Balog, Aaron; Geib, Steven J.; Curran, Dennis, P.
Journal of Organic Chemistry, 1995 , vol. 60, # 2 p. 345 - 352
反应条件
boron trifluoride diethyl etherate in benzene
20 h; Yield given. Yields of byproduct given;
参考文献
Balog, Aaron; Geib, Steven J.; Curran, Dennis, P.
Journal of Organic Chemistry, 1995 , vol. 60, # 2 p. 345 - 352
反应条件
1: DABCO / 1,2-dimethoxy-ethane / Ambient temperature
2: p-TsOH / toluene / Heating
View Scheme
参考文献
Liu, Hsing-Jang; Dieck-Abularach, Teofilo
Heterocycles, 1987 , vol. 25, p. 245 - 249
反应条件
1: DABCO / 1,2-dimethoxy-ethane / Ambient temperature
2: p-TsOH / toluene / Heating
View Scheme
参考文献
Liu, Hsing-Jang; Dieck-Abularach, Teofilo
Heterocycles, 1987 , vol. 25, p. 245 - 249
反应条件
hydrogenchloride in methanol
4 h; Ambient temperature;
参考文献
Kasturi, T. R.; Reddy, Madhava
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1982 , vol. 21, # 10 p. 901 - 906
反应条件
boron trifluoride diethyl etherate; water in dichloromethane
1 h; Yield given. Yields of byproduct given;
参考文献
Balog, Aaron; Geib, Steven J.; Curran, Dennis, P.
Journal of Organic Chemistry, 1995 , vol. 60, # 2 p. 345 - 352
反应条件
potassium hydroxide in methanol
参考文献
Crispin; Vanstone; Whithurst
Journal of the Chemical Society. Perkin transactions 1, 1970 , vol. 1, p. 10 - 18
反应条件
boron trifluoride diethyl etherate; water
1 h; Yield given. Yields of byproduct given;
参考文献
Balog, Aaron; Geib, Steven J.; Curran, Dennis, P.
Journal of Organic Chemistry, 1995 , vol. 60, # 2 p. 345 - 352
