2,3-二氧代吲哚啉-5-羧酰胺合成路线 （共 3 条）
反应条件
1.1: EDC / dimethylformamide / 4 h / 20 °C 2.1: Et3N / dioxane / 24 h / 20 °C 2.2: NH3 / dioxane / 2 h / 20 °C View Scheme
参考文献
Zhou, Lu; Liu, Ying; Zhang, Weilin; Wei, Ping; Huang, Changkang; Pei, Jianfeng; Yuan, Yaxia; Lai, Luhua
Journal of Medicinal Chemistry, 2006 , vol. 49, # 12 p. 3440 - 3443
反应条件
1.1: H2SO4 / 0.5 h / 90 °C 2.1: EDC / dimethylformamide / 4 h / 20 °C 3.1: Et3N / dioxane / 24 h / 20 °C 3.2: NH3 / dioxane / 2 h / 20 °C View Scheme
参考文献
Zhou, Lu; Liu, Ying; Zhang, Weilin; Wei, Ping; Huang, Changkang; Pei, Jianfeng; Yuan, Yaxia; Lai, Luhua
Journal of Medicinal Chemistry, 2006 , vol. 49, # 12 p. 3440 - 3443
反应条件
1.1: hydroxylamine hydrochloride; Na2SO4; H2SO4 / H2O / Heating 2.1: H2SO4 / 0.5 h / 90 °C 3.1: EDC / dimethylformamide / 4 h / 20 °C 4.1: Et3N / dioxane / 24 h / 20 °C 4.2: NH3 / dioxane / 2 h / 20 °C View Scheme
参考文献
Zhou, Lu; Liu, Ying; Zhang, Weilin; Wei, Ping; Huang, Changkang; Pei, Jianfeng; Yuan, Yaxia; Lai, Luhua
Journal of Medicinal Chemistry, 2006 , vol. 49, # 12 p. 3440 - 3443
