1-甲基-4-苯基-1,2,3,6-四氢吡啶合成路线 （共 27 条）
反应条件
1: 46 percent / 30percent H2O2 / 10percent Pd/C / CH2Cl2; ethanol / a) 60 deg C, 20 h, b) 60 deg C, 3 h
2: CH2Cl2 / 1 h / 0 °C
3: 67 percent / CH2Cl2; H2O / 0.25 h
View Scheme
参考文献
Weissman; Trevor; Chiba; Peterson; Caldera; Castagnoli Jr.; Baillie
Journal of Medicinal Chemistry, 1985 , vol. 28, # 8 p. 997 - 1001
反应条件
hydrogen; 10percent Pd/C in ethanol
T=20°C; P=4137.29 Torr; 10 h;
参考文献
Romanelli; Manetti; Scapecchi; Borea; Dei; Bartolini; Ghelardini; Gualtieri; Guandalini; Varani
Journal of Medicinal Chemistry, 2001 , vol. 44, # 23 p. 3946 - 3955
反应条件
manganese(IV) oxide; sodium hydroxide in benzene
T=20 - 40°C; 1.5 h;
参考文献
Soldatenkov; Temesgen; Polyanskii; Soldatova; Kolyadina; Golovtsov; Sergeeva
Chemistry of Heterocyclic Compounds, 2003 , vol. 39, # 4 p. 471 - 477
反应条件
manganese(IV) oxide in benzene
T=20°C; 2 h;
参考文献
Soldatenkov; Temesgen; Polyanskii; Soldatova; Kolyadina; Golovtsov; Sergeeva
Chemistry of Heterocyclic Compounds, 2003 , vol. 39, # 4 p. 471 - 477
反应条件
tertiary butyl peroxybenzenoate; copper(l) chloride in acetonitrile
0.5 h; Ambient temperatureisotope effect; relative oxidation rates with tris(1,10-phenanthroline)iron(III)tris(hexafluorophosphate); Rate constantMechanism;
参考文献
Khalil, Ashraf A.; Steyn, Salome; Castagnoli Jr., Neal
Chemical Research in Toxicology, 2000 , vol. 13, # 1 p. 31 - 35
反应条件
dihydrogen peroxide in ethanol
T=50°C; 8 h;
参考文献
Gessner, Wieslaw; Brossi, Arnold; Shen, Rong-sen; Fritz, Richard R.; Abell, Creed W.
Helvetica Chimica Acta, 1984 , vol. 67, p. 2037 - 2042
反应条件
monoamine oxidase-B
Mechanism;
参考文献
Franot, Christelle; Mabic, Stephane; Castagnol Jr., Neal
Bioorganic and Medicinal Chemistry, 1998 , vol. 6, # 3 p. 283 - 291
