4-溴-2,5-二氟苯甲酸合成路线 （共 4 条）
反应条件
1: 1.4-dibromo-2,5-difluorobenzene With n-butyllithium in diethyl ether; hexane T=-78°C; 0.0333333 h; Inert atmosphere; 2: carbon dioxide in diethyl ether; hexane T=-78 - 20°C; Inert atmosphere; 3: With hydrogenchloride in diethyl ether; hexane; water Inert atmosphere;
参考文献
Negoro, Kenji; Yonetoku, Yasuhiro; Misawa-Mukai, Hana; Hamaguchi, Wataru; Maruyama, Tatsuya; Yoshida, Shigeru; Takeuchi, Makoto; Ohta, Mitsuaki
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 17 p. 5235 - 5246
反应条件
1: 1.4-dibromo-2,5-difluorobenzene With n-butyllithium in hexanes; diethyl ether T=-78°C; 2.5 h; 2: carbon dioxide in hexanes; diethyl ether T=-78 - 20°C; 0.666667 h; 3: With hydrogenchloride in hexanes; diethyl ether; water
参考文献
ACHILLION PHARMACEUTICALS, INC.
Patent: WO2006/89054 A1, 2006 ;
Location in patent: Page/Page column 47-48 ;
反应条件
1: thionyl chloride / N,N-dimethyl-formamide / 1.5 h / 80 °C 2: ammonium hydroxide / chloroform / 0.5 h / 5 °C 3: trichlorophosphate / 2 h / 80 °C View Scheme
参考文献
Negoro, Kenji; Yonetoku, Yasuhiro; Misawa-Mukai, Hana; Hamaguchi, Wataru; Maruyama, Tatsuya; Yoshida, Shigeru; Takeuchi, Makoto; Ohta, Mitsuaki
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 17 p. 5235 - 5246
参考文献
Allergan Sales, Inc.
Patent: US6342602 B1, 2002 ;
Location in patent: Page column 26 ;
