1: With hydrogen bromide; acetic acid T=20°C; 46 h; 2: With sodium hydroxide in water T=0 - 35°C; pH=10;

sodium hydroxide in tetrahydrofuran; methanol; water T=20°C; 18 h; Large scale;

methylamine

1: hydrogenchloride; sodium cyanoborohydride / methanol; water; tetrahydrofuran; ethanol / |Large scale 2: sodium hydroxide / methanol; water; tetrahydrofuran / 18 h / 20 °C / |Large scale View Scheme

1.1: methylamine / water / 17 h / 20 °C / |Large scale 2.1: pyridinium tribromide / tetrahydrofuran; dichloromethane / 1 h / 0 - 5 °C / |Large scale 3.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct / N,N-dimethyl acetamide / 2 h / 20 - 95 °C / |Large scale 3.2: 9 h / 20 °C / |Large scale 4.1: hydrogenchloride; sodium cyanoborohydride / methanol; water; tetrahydrofuran; ethanol / |Large scale 5.1: sodium hydroxide / methanol; water; tetrahydrofuran / 18 h / 20 °C / |Large scale View Scheme

1.1: pyridinium tribromide / tetrahydrofuran; dichloromethane / 1 h / 0 - 5 °C / |Large scale 2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct / N,N-dimethyl acetamide / 2 h / 20 - 95 °C / |Large scale 2.2: 9 h / 20 °C / |Large scale 3.1: hydrogenchloride; sodium cyanoborohydride / methanol; water; tetrahydrofuran; ethanol / |Large scale 4.1: sodium hydroxide / methanol; water; tetrahydrofuran / 18 h / 20 °C / |Large scale View Scheme

1.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct / N,N-dimethyl acetamide / 2 h / 20 - 95 °C / |Large scale 1.2: 9 h / 20 °C / |Large scale 2.1: hydrogenchloride; sodium cyanoborohydride / methanol; water; tetrahydrofuran; ethanol / |Large scale 3.1: sodium hydroxide / methanol; water; tetrahydrofuran / 18 h / 20 °C / |Large scale View Scheme