2,7-二溴-9,9-二甲基芴合成路线 （共 14 条）
反应条件
1.1: n-butyllithium / hexane; tetrahydrofuran / 6 h / -70 - -65 °C / Inert atmosphere
1.2: -70 - 20 °C
1.3: pH 3
2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / toluene; water / 8 h / Reflux; Inert atmosphere
View Scheme
参考文献
Idemitsu Kosan Co., Ltd.
Patent: US8058450 B2, 2011 ;
反应条件
1: 2,2’-dibromo-9,9’-dimethyl-fluorene With n-butyllithium in tetrahydrofuran
T=-78°C; 1 h;
2: N,N-dimethyl-formamide in tetrahydrofuran
T=20°C; 2 h;
参考文献
Singh, Vijay; Wang, Shenliang; Kool, Eric T.
Journal of the American Chemical Society, 2013 , vol. 135, # 16 p. 6184 - 6191
反应条件
1: With n-butyllithium in tetrahydrofuran; hexane
T=-70 - -65°C; 6 h;
2: With tri-isopropoxy-borane in tetrahydrofuran; hexane
T=-70 - 20°C; 1 h;
3: With hydrogenchloride in tetrahydrofuran; hexane; water
pH=3;
参考文献
IDEMITSU KOSAN CO., LTD.
Patent: WO2006/100896 A1, 2006 ;
Location in patent: Page/Page column 32; 33 ;
反应条件
1: 2,2’-dibromo-9,9’-dimethyl-fluorene With n-butyllithium in tetrahydrofuran; hexane
T=-70 - -65°C; 6 h; Inert atmosphere;
2: tri-isopropoxy-borane in tetrahydrofuran; hexane
T=-70 - 20°C;
3: With hydrogenchloride in tetrahydrofuran; hexane; water
pH=3;
参考文献
Idemitsu Kosan Co., Ltd.
Patent: US8058450 B2, 2011 ;
Location in patent: Page/Page column 43-44 ;
