3-硝基-4-苯氧基-5-磺酰基苯甲酸合成路线 （共 10 条）
反应条件
sodium hydrogencarbonate in water T=85°C; 15 h;
参考文献
CONCERT PHARMACEUTICALS INC.; Tung, Roger
Patent: US2014/128469 A1, 2014 ;
Location in patent: Paragraph 0110; 0111 ;
反应条件
hydrogenchloride in water
参考文献
AUSPEX PHARMACEUTICALS, INC.
Patent: US2008/262086 A1, 2008 ;
Location in patent: Page/Page column 27 ;
参考文献
Hoechst Aktiengesellschaft
Patent: US4010273 A1, 1977 ;
反应条件
1: With lithium hydroxide; hydrogen; palladium 10 on activated carbon in water T=20°C; pH=8; 16 h; 2: With hydrogenchloride in water pH=3;
参考文献
AUSPEX PHARMACEUTICALS, INC.
Patent: US2008/262086 A1, 2008 ;
Location in patent: Page/Page column 28 ;
反应条件
lithium hydroxide; palladium in water
参考文献
Lovens Kemiske Fabrik Produktionsaktieselskab
Patent: US3971819 A1, 1976 ;
反应条件
1: With thionyl chloride
T=50°C;
2: With sodium hydrogencarbonate in ethyl acetate
参考文献
NEUROTHERAPEUTICS PHARMA, INC.; WANASKI, Stephen; COLLINS, Stephen; KINCAID, John
Patent: WO2012/18635 A2, 2012 ;
Location in patent: Page/Page column 111 ;
WO 2012/018635 A2
反应条件
in methanol; hexane; benzene
0.166667 h;
参考文献
CONCERT PHARMACEUTICALS INC.; Tung, Roger
Patent: US2014/128469 A1, 2014 ;
Location in patent: Paragraph 0110; 0112 ;
参考文献
Hoechst Aktiengesellschaft
Patent: US4010273 A1, 1977 ;
反应条件
1: thionyl chloride / 50 °C
2: acetonitrile / 20 °C
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参考文献
NEUROTHERAPEUTICS PHARMA, INC.; WANASKI, Stephen; COLLINS, Stephen; KINCAID, John
Patent: WO2012/18635 A2, 2012 ;
WO 2012/018635 A2
Title/Abstract Full Text Show Details
NEUROTHERAPEUTICS PHARMA, INC.; WANASKI, Stephen, P.; COLLINS, Stephen, D.; KINCAID, John; DODSON, Gary, Steven
Patent: WO2013/59648 A1, 2013 ;
参考文献
Lovens Kemiske Fabrik Produktionsaktieselskab
Patent: US3971819 A1, 1976 ;
