3-氨基-5-(氨基磺酰基)-4-苯氧基苯甲酸合成路线 （共 11 条）
反应条件
1: With lithium hydroxide; hydrogen; palladium 10 on activated carbon in water T=20°C; pH=8; 16 h; 2: With hydrogenchloride in water pH=3;
参考文献
AUSPEX PHARMACEUTICALS, INC.
Patent: US2008/262086 A1, 2008 ;
Location in patent: Page/Page column 28 ;
反应条件
lithium hydroxide; palladium in water
参考文献
Lovens Kemiske Fabrik Produktionsaktieselskab
Patent: US3971819 A1, 1976 ;
参考文献
Lovens Kemiske Fabrik Produktionsaktieselskab
Patent: US3971819 A1, 1976 ;
反应条件
1.1: sodium hydrogencarbonate / water / 85 °C 1.2: 20 °C 2.1: zinc; ammonium chloride; methanol / tetrahydrofuran / 20 °C / Inert atmosphere View Scheme
参考文献
NEUROTHERAPEUTICS PHARMA, INC.; WANASKI, Stephen; COLLINS, Stephen; KINCAID, John
Patent: WO2012/18635 A2, 2012 ;
WO 2012/018635 A2
反应条件
1.1: sodium hydrogencarbonate / water / 85 °C 1.2: 20 °C 2.1: zinc; ammonium chloride; methanol / tetrahydrofuran / 20 °C / Inert atmosphere View Scheme
参考文献
NEUROTHERAPEUTICS PHARMA, INC.; WANASKI, Stephen; COLLINS, Stephen; KINCAID, John
Patent: WO2012/18635 A2, 2012 ;
WO 2012/018635 A2
反应条件
sulfuric acid; NaOAc·3H2O; sodium hydrogencarbonate; toluene-4-sulfonic acid; acetic acid; benzyl alcohol; nickel monoaluminide in ethanol; cyclohexane; water
参考文献
USV Pharmaceutical Corp.
Patent: US4596791 A1, 1986 ;
US 4596791 A
参考文献
Lovens Kemiske Fabrik Produktionsaktieselskab
Patent: US3971819 A1, 1976 ;
反应条件
in sodium hydroxide; diethyl ether; ethanol
参考文献
Lovens Kemiske Fabrik Produktionsaktieselskab
Patent: US3971819 A1, 1976 ;
参考文献
Hoffmann-La Roche Inc.
Patent: US4118587 A1, 1978 ;
参考文献
Ciba-Geigy Corporation
Patent: US4176190 A1, 1979 ;
