反应条件
1: SOCl2 / dimethylformamide / 1 h / 80 °C
2: AlCl3 / dimethylformamide / 1 h / 90 °C
3: 85 percent / dimethylsulfoxide / 2 h / 80 °C
4: 95 percent / NH2NH2*H2O, KOH / bis-(2-hydroxy-ethyl) ether / 4 h / Heating
5: 95 percent / diethyl ether / 12 h / 0 °C
6: 90 percent / LiAlH4 / diethyl ether / 4 h / Heating
7: 88 percent / Me3SiI / CH2Cl2 / 24 h / Ambient temperature
8: 1.) n-BuLi / 1.) THF, -78 deg C, 60 min, 2.) THF, a) -78 deg C, 30 min, b) RT, 45 min
9: 89 percent / concd H2SO4 / 24 h / Heating
10: 95 percent / LiAlH4 / diethyl ether / 4 h / Heating
11: 85 percent / Me3SiI / CH2Cl2 / 24 h / Ambient temperature
12: 82 percent / dimethylsulfoxide / 2 h / 80 °C
13: 91 percent / KOH / ethane-1,2-diol / 6 h / Heating
14: 95 percent / diethyl ether / 12 h / 0 °C
15: 1.) Tl(OCOCF3)3, 2.) aq. KI / 1.) TFA, RT, 5 d, 2.) TFA, 15 min
16: 95 percent / 1 N NaOH / ethanol / 1.5 h / Heating
View Scheme
参考文献
Goodman, M. M.; Kirsch, G.; Knapp, F. F.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 3 p. 390 - 397
