反应条件
1: 100 percent / 15 h / 140 °C
2: 1.) 1M NaN(SiMe3)2 / 1.) THF, a) r.t., 30 min., b) reflux, 1 h, 2.) THF, a) 0 deg C, 1 h, r.t., 15 h
3: diethyl ether
4: 97 percent / H2 / 10percent Pd/C / ethyl acetate
5: 90 percent / NaOMe / methanol / Ambient temperature
6: 80 percent / pyridinium chlorochromate / CH2Cl2 / warming with a H2O bath
7: 1.) NaN(SiMe3)2 / 1.) THF, a) r.t., 30 min., b) reflux, 1 h, 2.) THF, a) -20 deg C , 1 h, b) r.t., 15 h
8: TsOH / methanol
9: 93 percent / NaOH / methanol / 27 h / Heating
View Scheme
参考文献
Muller; Schmidt
Helvetica Chimica Acta, 1993 , vol. 76, # 1 p. 616 - 630
