1.1: isobutyl chloroformate; N-methylmorpholine / CH2Cl2 / 0.5 h / Heating
1.2: 86 percent / CH2Cl2 / 0.5 h / Heating
2.1: NH3(gas); mercuric chloride / tetrahydrofuran / 3 h / 0 - 20 °C
3.1: 7.0 g / NH4OAc; AcOH / 12 h / 20 °C
4.1: Pd(OAc)2; TEA; triethylsilane / CH2Cl2 / 3 h / 20 °C
View Scheme
参考文献
Bock, Mark G.; DiPardo, Robert M.; Evans, Ben E.; Rittle, Kenneth E.; Veber, Daniel F.; et al.
Journal of Organic Chemistry, 1987 , vol. 52, # 15 p. 3232 - 3239
dicyclohexyl-carbodiimide in dichloromethane
T=-20°C; 2 h;
参考文献
Belokon, Yuri N.; Bulychev, Alexander G.; Vitt, Sergei V.; Struchkov, Yuri T.; Batsanov, Andrei S.; et al.
Journal of the American Chemical Society, 1985 , vol. 107, # 14 p. 4252 - 4259
Ryzhov, M. G.; Timofeev, V.A.; Kazika, A.I.; Nosova, N. A.; Vauchskii, Yu. P.; Istomina, V. P.
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