甲基2-羟基-4,5-二甲氧基苯甲酸酯合成路线 （共 18 条）
反应条件
selective mono-demethylation; Yield given;
参考文献
Rama Rao; Yadav; Kishta Reddy; Upender, Velaparthi
Tetrahedron Letters, 1991 , vol. 32, # 38 p. 5199 - 5202
参考文献
Takei; Miyajima; Ono
Chemische Berichte, 1932 , vol. 65, p. 1041,1046
参考文献
v. Hemmelmayr
Monatshefte fuer Chemie, 1914 , vol. 35, p. 4
反应条件
1: 48 percent / KF / dimethylformamide / 75 °C
2: 1.) aq. Na2S2O4, 2.) conc. H2SO4 / 2.) 20 -> 60 deg C
3: 70 percent / NaN(TMS)2 / tetrahydrofuran / 20 °C
4: 65 percent / NaHCO3 / Pd(OAc)2 / various solvent(s) / 15 h / 95 °C
5: 36 percent / CH2Cl2 / 4 h / Irradiation
View Scheme
参考文献
Rama Rao; Yadav; Kishta Reddy; Upender, Velaparthi
Tetrahedron Letters, 1991 , vol. 32, # 38 p. 5199 - 5202
反应条件
1: K2CO3 / dimethylformamide
2: aq. Na2S2O4
3: K2CO3 / acetone / 6 h / Heating
4: aq. KOH / ethanol / 10 h / 25 °C
5: PPE / CHCl3 / 36 h / 25 °C
6: aq. KOH / ethanol / 8 h / 25 °C
8: PCC / CH2Cl2 / 15 h / 25 °C
9: 82 percent / K2CO3 / methanol / 36 h / 25 °C
10: 95 percent / ceric ammonium nitrate / acetonitrile; H2O
11: 85 percent / Et3N*BCl3 / CH2Cl2 / 0.25 h / 0 °C
12: NaBH4
View Scheme
参考文献
Rama Rao; Yadav; Kishta Reddy; Upender, Velaparthi
Tetrahedron Letters, 1991 , vol. 32, # 38 p. 5199 - 5202
反应条件
1: potassium carbonate; acetone
2: aqueous KOH-solution
4: methanol; platinum / Hydrogenation
View Scheme
参考文献
Arnold; Bortnick
Journal of the American Chemical Society, 1945 , vol. 67, p. 806
参考文献
Arnold; Bordwell
Journal of the American Chemical Society, 1942 , vol. 64, p. 2983,2985
反应条件
1: potassium carbonate; acetone
2: aqueous KOH-solution
View Scheme
参考文献
Arnold; Bortnick
Journal of the American Chemical Society, 1945 , vol. 67, p. 806
