4-氨基-3,5-二氯-2,6-二氟嘧啶合成路线 （共 14 条）
反应条件
ammonium hydroxide T=20°C;
参考文献
Liu; Luo; Mozdziesz; Lin; Dutschman; Gullen; Cheng; Sartorelli
Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 12 p. 1975 - 2000
参考文献
Banks,R.E.; Madany,I.M.
Journal of Fluorine Chemistry, 1985 , vol. 30, p. 211
参考文献
Gmelin Handbook: F: PerFHalOrg.5, 4.1.1.3, page 180 - 219
反应条件
zinc 8 h; Product distribution; Further Variations:Reagentstime;
参考文献
Selivanova, Galina A.; Gurskaya, Larisa Yu.; Pokrovskii, Leonid M.; Kollegov, Vitaliy F.; Shteingarts, Vitaliy D.
Journal of Fluorine Chemistry, 2004 , vol. 125, # 12 p. 1829 - 1834
反应条件
1: 92.6 percent / H2, Et3N / 20percent Pd/C / methanol / 72 h / 2689.2 Torr 2: 74.1 percent / 1N aq. NaOH / 24 h / Heating View Scheme
参考文献
McNamara; Cook
Journal of Medicinal Chemistry, 1987 , vol. 30, # 2 p. 340 - 347
反应条件
hydrogen; triethylamine; palladium on activated charcoal in ethanol P=2585.74 Torr; 18 h;
参考文献
Nucleosides, Nucleotides and Nucleic Acids, , vol. 20, # 12 p. 1975 - 2000
反应条件
hydrogen; triethylamine; palladium on activated charcoal in methanol P=2689.2 Torr; 72 h;
参考文献
McNamara; Cook
Journal of Medicinal Chemistry, 1987 , vol. 30, # 2 p. 340 - 347
反应条件
byproducts: NaF; reflux, 2 h;;
参考文献
Gmelin Handbook: F: PerFHalOrg.5, 4.1.1.3, page 180 - 219
反应条件
in N,N-dimethyl-formamide 4h, steam bath;;
参考文献
Gmelin Handbook: F: PerFHalOrg.5, 4.1.1.3, page 180 - 219
反应条件
1: 33 percent / Et3N; H2 / 10 percent Pd/C / ethanol / 18 h / 2585.74 Torr
2: 76 percent / conc. H2SO4; KNO3 / 0 - 20 °C
3: 89 percent / conc. H2SO4 / 20 °C
View Scheme
参考文献
Liu; Luo; Mozdziesz; Lin; Dutschman; Gullen; Cheng; Sartorelli
Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 12 p. 1975 - 2000
