4-氨基-3,5-二氯-2,6-二氟嘧啶合成路线 （共 14 条）
反应条件
1: 33 percent / Et3N; H2 / 10 percent Pd/C / ethanol / 18 h / 2585.74 Torr
2: 76 percent / conc. H2SO4; KNO3 / 0 - 20 °C
3: 89 percent / conc. H2SO4 / 20 °C
4: 92 percent / H2 / Raney Ni / ethanol
View Scheme
参考文献
Liu; Luo; Mozdziesz; Lin; Dutschman; Gullen; Cheng; Sartorelli
Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 12 p. 1975 - 2000
反应条件
1: 33 percent / Et3N; H2 / 10 percent Pd/C / ethanol / 18 h / 2585.74 Torr
2: 76 percent / conc. H2SO4; KNO3 / 0 - 20 °C
3: 89 percent / conc. H2SO4 / 20 °C
4: 92 percent / H2 / Raney Ni / ethanol
View Scheme
参考文献
Liu; Luo; Mozdziesz; Lin; Dutschman; Gullen; Cheng; Sartorelli
Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 12 p. 1975 - 2000
反应条件
hydrogen; triethylamine; palladium on activated charcoal in ethanol
P=2585.74 Torr; 18 h;
参考文献
Sartorelli, Alan C.; Cheng, Yung-Chi; Liu, Mao-Chin
Patent: US2004/116362 A1, 2004 ;
Location in patent: Page/Page column 11; Figure 11 ;
反应条件
1: 57 percent / Et3N; H2 / 10 percent Pd/C / ethanol / 18 h / 2585.74 Torr
2: 76.4 percent / conc. H2SO4; KNO3 / 0 - 20 °C
3: 82 percent / conc. H2SO4 / 20 °C
View Scheme
参考文献
Liu; Luo; Mozdziesz; Lin; Dutschman; Gullen; Cheng; Sartorelli
Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 12 p. 1975 - 2000
