5-氨基-2-甲基苯甲酸合成路线 （共 14 条）
反应条件
1.1: sulfuric acid; sodium nitrite / water / 0.5 h / 0 °C 1.2: 0.5 h / |Reflux 2.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 70 °C 3.1: N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile / tetrachloromethane / 3 h / 72 °C View Scheme
参考文献
Baur, Benjamin; Storch, Kirsten; Martz, Kathrin E.; Goettert, Marcia I.; Richters, Andre; Rauh, Daniel; Laufer, Stefan A.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 21 p. 8561 - 8578
反应条件
1: With sulfuric acid; sodium nitrite in water T=0°C; 0.5 h; 2: in water 0.5 h; Reflux;
参考文献
Baur, Benjamin; Storch, Kirsten; Martz, Kathrin E.; Goettert, Marcia I.; Richters, Andre; Rauh, Daniel; Laufer, Stefan A.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 21 p. 8561 - 8578
反应条件
1: With sulfuric acid T=-10°C; Heating; 2: With sodium nitrite in water T=-10 - 100°C; 3: With sulfuric acid in methanol Reflux;
参考文献
Takeda Pharmaceutical Company Limited
Patent: EP2103620 A1, 2009 ;
Location in patent: Page/Page column 67 ;
反应条件
1.1: sulfuric acid; sodium nitrite / water / 0.5 h / 0 °C
1.2: 0.5 h / |Reflux
2.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 70 °C
View Scheme
参考文献
Baur, Benjamin; Storch, Kirsten; Martz, Kathrin E.; Goettert, Marcia I.; Richters, Andre; Rauh, Daniel; Laufer, Stefan A.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 21 p. 8561 - 8578
