4-氨基-2,3-二氟-5-硝基苯甲酸合成路线 （共 7 条）
反应条件
1: With ammonia in water T=0 - 20°C; 2.5 h; 2: With hydrogenchloride in water pH=0;
参考文献
US2004/116710 A1, ;
Page 6; 16 ;
US 20040116710 A1
反应条件
1: sulfuric acid; nitric acid / 2.5 h 2: ammonium hydroxide / water / 2.5 h / 0 - 20 °C View Scheme
反应条件
diazomethyl-trimethyl-silane in tetrahydrofuran; methanol; hexane T=0 - 20°C; 0.5 h;
参考文献
WO2007/76245 A2, ;
Page/Page column 19 ;
WO 2007/076245 A2
反应条件
methanol in tetrahydrofuran T=0 - 20°C; 0.5 h;
参考文献
US2004/116710 A1, ;
Page 6; 16 ;
US 20040116710 A1
反应条件
chloro-trimethyl-silane 15.0833 h; Heating / reflux;
参考文献
WO2007/2092 A1, ;
Page/Page column 51 ;
WO 2007/002092 A1
反应条件
acetic acid in tetrahydrofuran; methanol
参考文献
US2003/216460 A1, ;
US 20030216460 A1
反应条件
1: hexane; tetrahydrofuran; methanol / 0.5 h / 0 - 20 °C / |Inert atmosphere
2: anhydrous xylene / 144 h / 140 °C / |Inert atmosphere
View Scheme
参考文献
NOVARTIS PHARMA AG; AMGEN INC.; HUANG, Xizhong; PETERS, Malte; SCHUMACHER, Karl, Maria; CAO, Zhu, Alexander; GANSERT, Jennifer, Lorraine; CHANG, David, Dong, Eun; BELTRAN, Pedro
Patent: WO2013/142182 A2, 2013 ;
