4-氨基-2,3-二氟-5-硝基苯甲酸甲酯合成路线 （共 11 条）
反应条件
diazomethyl-trimethyl-silane in tetrahydrofuran; methanol; hexane T=0 - 20°C; 0.5 h;
参考文献
WO2007/76245 A2, ;
Page/Page column 19 ;
WO 2007/076245 A2
反应条件
methanol in tetrahydrofuran T=0 - 20°C; 0.5 h;
参考文献
US2004/116710 A1, ;
Page 6; 16 ;
US 20040116710 A1
反应条件
chloro-trimethyl-silane 15.0833 h; Heating / reflux;
参考文献
WO2007/2092 A1, ;
Page/Page column 51 ;
WO 2007/002092 A1
反应条件
acetic acid in tetrahydrofuran; methanol
参考文献
US2003/216460 A1, ;
US 20030216460 A1
反应条件
1: ammonium hydroxide / water / 2.5 h / 0 - 20 °C 2: hexane; tetrahydrofuran; methanol / 0.5 h / 0 - 20 °C / |Inert atmosphere View Scheme
反应条件
1: sulfuric acid; nitric acid / 2.5 h 2: ammonium hydroxide / water / 2.5 h / 0 - 20 °C 3: hexane; tetrahydrofuran; methanol / 0.5 h / 0 - 20 °C / |Inert atmosphere View Scheme
反应条件
in xylene T=125°C; 16 h;
参考文献
Wallace, Eli M.; Lyssikatos, Joseph P.; Marlow, Allison L.; Hurley, T. Brian
Patent: US2003/232869 A1, 2003 ;
Location in patent: Page 10; 17 ;
US 20030232869 A1
反应条件
aniline in dichloromethane
参考文献
Wallace, Eli M.; Lyssikatos, Joseph P.; Marlow, Allison L.; Hurley, T. Brian
Patent: US2003/216460 A1, 2003 ;
US 20030216460 A1
反应条件
ammonia in water
T=20°C; 192 h;
参考文献
ARRAY BIOPHARMA INC.; ASTRAZENECA AB
Patent: WO2007/2092 A1, 2007 ;
Location in patent: Page/Page column 51-52 ;
WO 2007/002092 A1
反应条件
ammonia in 1,4-dioxane; water
T=79 - 105°C; P=150.015 - 2025.2 Torr; 1.33333 h; Product distribution / selectivity;
参考文献
ARRAY BIOPHARMA INC.; ASTRAZENECA AB
Patent: WO2007/2157 A2, 2007 ;
Location in patent: Page/Page column 65; 77 ;
WO 2007/002157 A2
