6,9-二氟-11,17-二羟基-16-甲基-3-氧代雄甾-1,4-二烯-17-羧酸合成路线 （共 11 条）
反应条件
water; periodic acid in tetrahydrofuran T=20°C; 1 h;
参考文献
US2010/99654 A1, ;
Page/Page column 5 ;
反应条件
1: 6α, 9α-difluoro-11β-hydroxy-16α-methyl-3-oxo-17α-hydroxy-androsta-1,4-diene-17β-carboxylic acid With 1,1'-carbonyldiimidazole in tetrahydrofuran T=5°C; 18 h; Inert atmosphere; 2: methyl thioacetic acid in tetrahydrofuran T=5 - 25°C; 7 h; Inert atmosphere; Product distribution / selectivity;
参考文献
US2009/275767 A1, ;
Page/Page column 3 ;
反应条件
1: dimethylformamide / 4 h / Ambient temperature 2: H2S / dimethylformamide 3: Et3N / CH2Cl2 / 0.75 h 4: Et2NH / acetone / 1 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 37, # 22 p. 3717 - 3729
反应条件
1: dimethylformamide / 4 h / Ambient temperature 2: H2S / dimethylformamide 3: Et3N / CH2Cl2 / 0.75 h 4: Et2NH / acetone / 1 h 5: 67.1 percent / KHCO3 / dimethylformamide / 0.25 h / 22 - 25 °C View Scheme
参考文献
Phillipps; Bailey; Bain; Borella; Buckton; Clark; Doherty; English; Fazakerley; Laing; Lane-Allman; Robinson; Sandford; Sharratt; Steeples; Stonehouse; Williamson
Journal of Medicinal Chemistry, 1994 , vol. 37, # 22 p. 3717 - 3729
反应条件
1: With 1,1'-carbonyldiimidazole in N,N-dimethyl-formamide T=20°C; 4 h; Inert atmosphere; 2: With hydrogen sulfide in N,N-dimethyl-formamide T=20°C; 4.5 h; Inert atmosphere;
参考文献
Zheng, Jin; Lai, Qinglin; Dai, Yiru; Zhao, Qingjie; Shen, Jingshan
Organic Preparations and Procedures International, 2008 , vol. 40, # 6 p. 566 - 566
反应条件
1: With diethylamine; triethylamine in acetone T=0°C; 2.33333 h; 2: With hydrogenchloride in water pH=2;
参考文献
Alpharma APS
Patent: EP1466920 A1, 2004 ;
Location in patent: Page 7 ;
反应条件
1: With triethylamine in acetone T=10 - 30°C; 4 h; 2: With diethylamine in acetone T=10 - 20°C; 1 h;
参考文献
SUN PHARMACEUTICAL INDUSTRIES LIMITED
Patent: US2005/256325 A1, 2005 ;
Location in patent: Page/Page column 8 ;
反应条件
hydrogenchloride; triethylamine in hexadeuterioacetone; water
参考文献
US2014/148593 A1, ;
Page/Page column ;
反应条件
hydrogenchloride in hexadeuterioacetone; water
参考文献
US2014/148593 A1, ;
Page/Page column ;
反应条件
hydrogenchloride; triethylamine in water; acetone
参考文献
Barkalow, Jufang; Chamberlin, Steven A.; Cooper, Arthur J.; Hossain, Azad; Hufnagel, John J.; Langridge, Denton
Patent: US2002/133032 A1, 2002 ;
