4-(4-氨基苯氧基)-N-甲基-2-吡啶甲酰胺合成路线 （共 22 条）
反应条件
1: With potassium tert-butylate in tetrahydrofuran; N,N-dimethyl-formamide T=20°C; 2 h; Inert atmosphere; 2: 4-chloropicolinohydrazide With potassium carbonate in tetrahydrofuran; N,N-dimethyl-formamide T=80°C; 6 h; Inert atmosphere;
参考文献
WO2012/112570 A1, ;
Page/Page column 57 ;
WO 2012/112570 A1
反应条件
potassium tert-butylate in N,N-dimethyl-formamide T=25°C; 1 h;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 8 p. 2220 - 2223
反应条件
hydrogen; nickel in tetrahydrofuran; methanol T=20°C; Product distribution / selectivity;
参考文献
WO2005/82853 A1, ;
Page/Page column 209 ;
WO 2005/082853 A1
反应条件
1: 4-amino-phenol With sodium hydride in N,N-dimethyl-formamide T=20°C; 2 h; 2: 4-chloro-N-methyl-2-pyridinecarboxamide With potassium carbonate in N,N-dimethyl-formamide T=80°C; 8 h;
参考文献
WO2006/71940 A2, ;
Page/Page column 356 ;
WO 2006/071940 A2
反应条件
1: 4-amino-phenol With potassium tert-butylate in tetrahydrofuran; N,N-dimethyl-formamide T=20°C; 2 h; Inert atmosphere; 2: 4-chloro-pyridine-2-carboxylic acid amide With potassium carbonate in tetrahydrofuran; N,N-dimethyl-formamide T=80°C; 6 h; Inert atmosphere;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 13 p. 3732 - 3737
反应条件
potassium tert-butylate; potassium carbonate in N,N-dimethyl-formamide
参考文献
US2002/65296 A1, ;
US 20020065296 A1
反应条件
1.1: thionyl chloride / N,N-dimethyl-formamide / 17.5 h / 50 °C / Inert atmosphere; Reflux 2.1: tetrahydrofuran; methanol / 0 - 20 °C 3.1: potassium tert-butylate / N,N-dimethyl-formamide / 2 h / 20 °C 3.2: 6 h / 80 °C / Inert atmosphere View Scheme
参考文献
Molecules, , vol. 16, # 6 p. 5130 - 5141
反应条件
1.1: tetrahydrofuran; methanol / 0 - 20 °C 2.1: potassium tert-butylate / N,N-dimethyl-formamide / 2 h / 20 °C 2.2: 6 h / 80 °C / Inert atmosphere View Scheme
参考文献
Molecules, , vol. 16, # 6 p. 5130 - 5141
参考文献
US2003/144278 A1, ;
US 20030144278 A1
参考文献
US2003/144278 A1, ;
US 20030144278 A1
