4-(4-氨基苯氧基)-N-甲基-2-吡啶甲酰胺合成路线 （共 22 条）
反应条件
1.1: tetrahydrofuran; methanol / 3 h / 2 - 20 °C 2.1: potassium tert-butylate / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere 2.2: 10 h / 80 - 85 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 20, # 9 p. 2923 - 2929
参考文献
Riedl, Bernd; Dumas, Jacques; Khire, Uday; Lowinger, Timothy B.; Scott, William J.; Smith, Roger A.; Wood, Jill E.; Monahan, Mary-Katherine; Natero, Reina; Renick, Joel; Sibley, Robert N.
Patent: US2001/11135 A1, 2001 ;
US 20010011135 A1
参考文献
Riedl, Bernd; Dumas, Jacques; Khire, Uday; Lowinger, Timothy B.; Scott, William J.; Smith, Roger A.; Wood, Jill E.; Monahan, Mary-Katherine; Natero, Reina; Renick, Joel; Sibley, Robert N.
Patent: US2001/11135 A1, 2001 ;
US 20010011135 A1
Title/Abstract Full Text Show Details
BAYER CORPORATION
Patent: US2002/165394 A1, 2002 ;
US 20020165394 A1
Title/Abstract Full Text Show Details
BAYER CORPORATION
Patent: US2003/181442 A1, 2003 ;
参考文献
BAYER CORPORATION
Patent: US2002/65296 A1, 2002 ;
US 20020065296 A1
反应条件
1: With potassium hydroxide; water T=100°C; 2 h; 2: With water pH=5;
参考文献
Cai, Xiong; Qian, Changgeng; Gould, Stephen; Zhai, Haixiao
Patent: US2008/234332 A1, 2008 ;
Location in patent: Page/Page column 22; 25 ;
US 20080234332 A1
参考文献
Riedl, Bernd; Dumas, Jacques; Khire, Uday; Lowinger, Timothy B.; Scott, William J.; Smith, Roger A.; Wood, Jill E.; Monahan, Mary-Katherine; Natero, Reina; Renick, Joel; Sibley, Robert N.
Patent: US2001/11135 A1, 2001 ;
US 20010011135 A1
反应条件
in chlorobenzene T=70 - 75°C; 0.25 h; Product distribution / selectivity;
参考文献
Rossetto, Pierluigi; MacDonald, Peter Lindsay; Canavesi, Augusto
Patent: US2009/253913 A1, 2009 ;
Location in patent: Page/Page column 6-7 ;
反应条件
pyridine T=80°C; 3 h;
参考文献
Zhang, Lijuan; Xia, Wenpin; Wang, Bo; Luo, Yu; Lu, Wei
Synthetic Communications, 2011 , vol. 41, # 21 p. 3140 - 3146
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in dimethyl sulfoxide T=110 - 120°C; 12 - 18 h; Product distribution / selectivity;
参考文献
CIPLA LIMITED
Patent: US2010/311980 A1, 2010 ;
Location in patent: Page/Page column 23 ;
反应条件
triethylamine in N,N-dimethyl-formamide T=125°C; 96 h; Product distribution / selectivity;
参考文献
CIPLA LIMITED
Patent: US2010/311980 A1, 2010 ;
Location in patent: Page/Page column 24 ;
