反应条件
1.1: lithium 2,2,6,6-tetramethylpiperidine; t-Bu2Zn / tetrahydrofuran / -78 - -30 °C
1.2: 78 percent / I2 / tetrahydrofuran / 2 h / 20 °C
2.1: 70 percent / TBAF*3H2O / PdCl2(PPh3)2 / 60 °C
3.1: 67 percent / 1,3-bis(2,6-diisopropylphenyl)imidazolium chloride; t-BuOK / Pd(OAc)2 / toluene / Heating
4.1: BBr3 / CH2Cl2 / 16 h / -78 - 20 °C
4.2: 81 percent / KHCO3 / CH2Cl2; methanol / 1 h / 0 - 20 °C
5.1: 78 percent / NaH / dimethylformamide / 20 °C
6.1: CH2Cl2 / 2 h / 20 °C
6.2: 75 percent / 1,1,1,3,3,3-hexamethyldisilazane / CH2Cl2 / 20 °C
View Scheme
参考文献
Sanz, Roberto; Castroviejo, M. Pilar; Guilarte, Veronica; Perez, Antonio; Fananas, Francisco J.
Journal of Organic Chemistry, 2007 , vol. 72, # 14 p. 5113 - 5118
