5,6-二甲基-2-硫代尿苷合成路线 （共 7 条）
反应条件
potassium tert-butylate in ethanol 0.25 h; Reflux;
参考文献
ABBVIE INC.; DEKHTYAR, Tatyana; GOMTSYAN, Arthur; MOLLA, M-Akhteruzzaman; VASUDEVAN, Anil; NG, Teresa (Iok Chan); SHAFEEV, Mikhail
Patent: WO2013/123401 A1, 2013 ;
Location in patent: Page/Page column 39 ;
参考文献
Roth, Joshua; Minond, Dmitriy; Darout, Etzer; Liu, Qin; Lauer, Janelle; Hodder, Peter; Fields, Gregg B.; Roush, William R.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 23 p. 7180 - 7184
反应条件
1: aqueous H2O2 / 70 - 90 °C 2: POCl3 View Scheme
参考文献
Williams et al.
Journal of the American Chemical Society, 1937 , vol. 59, p. 526,527
反应条件
2: aqueous HCl View Scheme
参考文献
Senda; Suzui
Chemical and Pharmaceutical Bulletin, 1958 , vol. 6, p. 476,478
反应条件
dihydrogen peroxide T=70 - 90°C;
参考文献
Williams et al.
Journal of the American Chemical Society, 1937 , vol. 59, p. 526,527
反应条件
water; chloroacetic acid Reflux;
参考文献
ABBVIE INC.; DEKHTYAR, Tatyana; GOMTSYAN, Arthur; MOLLA, M-Akhteruzzaman; VASUDEVAN, Anil; NG, Teresa (Iok Chan); SHAFEEV, Mikhail
Patent: WO2013/123401 A1, 2013 ;
Location in patent: Page/Page column 40 ;
反应条件
1: chloroacetic acid; water / |Reflux 2: trichlorophosphate; N,N-dimethyl-formamide / |Reflux; |Inert atmosphere View Scheme
参考文献
ABBVIE INC.; DEKHTYAR, Tatyana; GOMTSYAN, Arthur; MOLLA, M-Akhteruzzaman; VASUDEVAN, Anil; NG, Teresa (Iok Chan); SHAFEEV, Mikhail
Patent: WO2013/123401 A1, 2013 ;
