4-(3,5-双三氟甲基苯基)噻唑-2-胺合成路线 (共 2 条)
反应条件
1: 1-(3,5-bis(trifluoromethyl)-phenyl)ethan-1-one With phenyltrimethylammonium tribromide in tetrahydrofuran T=20°C; 5 h; 2: thiourea in ethanol 0.5 h; Heating / reflux;
参考文献
EP1512396 A1, ;
Page/Page column 176 ;
反应条件
1: 1-(3,5-bis(trifluoromethyl)-phenyl)ethan-1-one With phenyltrimethylammonium tribromide in tetrahydrofuran T=20°C; 5 h; 2: thiourea With sodium sulfate in ethanol 0.5 h; Heating / reflux;
参考文献
EP1535609 A1, ;
Page/Page column 117 ;