N-环丙基-4-甲基-3-硝基-2-吡啶胺合成路线 （共 7 条）
反应条件
in anhydrous xylene T=105°C; 4 h; Sealed vessel;
参考文献
Khunnawutmanotham, Nisachon; Chimnoi, Nitirat; Techasakul, Supanna; Thitithanyanont, Arunee; Saparpakorn, Patchreenart; Hannongbua, Supa; Choowongkomon, Kiattawee; Pungpo, Pornpan
Beilstein Journal of Organic Chemistry, 2009 , vol. 5, art. no. A36
反应条件
1.1: 55 percent / H2 / Raney Ni / ethanol / 4 h / 2068.59 Torr 2.1: 71 percent / N,N-diisopropylethylamine / ethyl acetate / 18 h / 20 °C 3.1: 30 percent / potassium acetate; acetic acid; bromine / 1 h / 20 °C 4.1: 92.7 percent / sodium hydride; pyridine / 0.5 h / Heating 5.1: 64.9 percent / tetrakis(triphenylphosphine)palladium / dimethylformamide / 1.5 h / 90 °C 6.1: ozone / methanol; CH2Cl2 / -78 °C 6.2: 47 percent / dimethyl sulfide / methanol; CH2Cl2 View Scheme
参考文献
Grozinger, Karl G.; Byrne, Denis P.; Nummy, Laurence J.; Ridges, Michael D.; Salvagno, Annette
Journal of Heterocyclic Chemistry, 2000 , vol. 37, # 2 p. 229 - 239
反应条件
1: 55 percent / H2 / Raney Ni / ethanol / 4 h / 2068.59 Torr 2: 71 percent / N,N-diisopropylethylamine / ethyl acetate / 18 h / 20 °C View Scheme
参考文献
Grozinger, Karl G.; Byrne, Denis P.; Nummy, Laurence J.; Ridges, Michael D.; Salvagno, Annette
Journal of Heterocyclic Chemistry, 2000 , vol. 37, # 2 p. 229 - 239
反应条件
1: 55 percent / H2 / Raney Ni / ethanol / 4 h / 2068.59 Torr 2: 71 percent / N,N-diisopropylethylamine / ethyl acetate / 18 h / 20 °C 3: 30 percent / potassium acetate; acetic acid; bromine / 1 h / 20 °C View Scheme
参考文献
Grozinger, Karl G.; Byrne, Denis P.; Nummy, Laurence J.; Ridges, Michael D.; Salvagno, Annette
Journal of Heterocyclic Chemistry, 2000 , vol. 37, # 2 p. 229 - 239
反应条件
1: With hydrogenchloride; SnCl2·2H2O; acetic acid in water T=20°C; 2: With sodium hydroxide in water pH=12; Cooling with ice;
参考文献
Khunnawutmanotham, Nisachon; Chimnoi, Nitirat; Techasakul, Supanna; Thitithanyanont, Arunee; Saparpakorn, Patchreenart; Hannongbua, Supa; Choowongkomon, Kiattawee; Pungpo, Pornpan
Beilstein Journal of Organic Chemistry, 2009 , vol. 5, art. no. A36
反应条件
1: 55 percent / H2 / Raney Ni / ethanol / 4 h / 2068.59 Torr 2: 71 percent / N,N-diisopropylethylamine / ethyl acetate / 18 h / 20 °C 3: 30 percent / potassium acetate; acetic acid; bromine / 1 h / 20 °C 4: 92.7 percent / sodium hydride; pyridine / 0.5 h / Heating 5: 64.9 percent / tetrakis(triphenylphosphine)palladium / dimethylformamide / 1.5 h / 90 °C View Scheme
参考文献
Grozinger, Karl G.; Byrne, Denis P.; Nummy, Laurence J.; Ridges, Michael D.; Salvagno, Annette
Journal of Heterocyclic Chemistry, 2000 , vol. 37, # 2 p. 229 - 239
反应条件
1: 55 percent / H2 / Raney Ni / ethanol / 4 h / 2068.59 Torr 2: 71 percent / N,N-diisopropylethylamine / ethyl acetate / 18 h / 20 °C 3: 30 percent / potassium acetate; acetic acid; bromine / 1 h / 20 °C 4: 92.7 percent / sodium hydride; pyridine / 0.5 h / Heating View Scheme
参考文献
Grozinger, Karl G.; Byrne, Denis P.; Nummy, Laurence J.; Ridges, Michael D.; Salvagno, Annette
Journal of Heterocyclic Chemistry, 2000 , vol. 37, # 2 p. 229 - 239
