N-[5-溴-2-(环丙基氨基)-4-甲基-3-吡啶基]-2-氯-3-吡啶甲酰胺合成路线 （共 9 条）
反应条件
1: 88 percent / xylene / 48 h / 75 °C 2: 55 percent / H2 / Raney Ni / ethanol / 4 h / 2068.59 Torr 3: 71 percent / N,N-diisopropylethylamine / ethyl acetate / 18 h / 20 °C 4: 30 percent / potassium acetate; acetic acid; bromine / 1 h / 20 °C View Scheme
参考文献
Grozinger, Karl G.; Byrne, Denis P.; Nummy, Laurence J.; Ridges, Michael D.; Salvagno, Annette
Journal of Heterocyclic Chemistry, 2000 , vol. 37, # 2 p. 229 - 239
反应条件
1: 55 percent / H2 / Raney Ni / ethanol / 4 h / 2068.59 Torr 2: 71 percent / N,N-diisopropylethylamine / ethyl acetate / 18 h / 20 °C 3: 30 percent / potassium acetate; acetic acid; bromine / 1 h / 20 °C View Scheme
参考文献
Grozinger, Karl G.; Byrne, Denis P.; Nummy, Laurence J.; Ridges, Michael D.; Salvagno, Annette
Journal of Heterocyclic Chemistry, 2000 , vol. 37, # 2 p. 229 - 239
反应条件
bromine; potassium acetate; acetic acid T=20°C; Bromination; 1 h;
参考文献
Grozinger, Karl G.; Byrne, Denis P.; Nummy, Laurence J.; Ridges, Michael D.; Salvagno, Annette
Journal of Heterocyclic Chemistry, 2000 , vol. 37, # 2 p. 229 - 239
反应条件
1: 71 percent / N,N-diisopropylethylamine / ethyl acetate / 18 h / 20 °C 2: 30 percent / potassium acetate; acetic acid; bromine / 1 h / 20 °C View Scheme
参考文献
Grozinger, Karl G.; Byrne, Denis P.; Nummy, Laurence J.; Ridges, Michael D.; Salvagno, Annette
Journal of Heterocyclic Chemistry, 2000 , vol. 37, # 2 p. 229 - 239
反应条件
1: thionyl chloride / 4 h / Heating 2: 71 percent / N,N-diisopropylethylamine / ethyl acetate / 18 h / 20 °C 3: 30 percent / potassium acetate; acetic acid; bromine / 1 h / 20 °C View Scheme
参考文献
Grozinger, Karl G.; Byrne, Denis P.; Nummy, Laurence J.; Ridges, Michael D.; Salvagno, Annette
Journal of Heterocyclic Chemistry, 2000 , vol. 37, # 2 p. 229 - 239
反应条件
1: 71 percent / N,N-diisopropylethylamine / ethyl acetate / 18 h / 20 °C 2: 30 percent / potassium acetate; acetic acid; bromine / 1 h / 20 °C View Scheme
参考文献
Grozinger, Karl G.; Byrne, Denis P.; Nummy, Laurence J.; Ridges, Michael D.; Salvagno, Annette
Journal of Heterocyclic Chemistry, 2000 , vol. 37, # 2 p. 229 - 239
反应条件
1.1: 92.7 percent / sodium hydride; pyridine / 0.5 h / Heating 2.1: 64.9 percent / tetrakis(triphenylphosphine)palladium / dimethylformamide / 1.5 h / 90 °C 3.1: ozone / methanol; CH2Cl2 / -78 °C 3.2: 47 percent / dimethyl sulfide / methanol; CH2Cl2 View Scheme
参考文献
Grozinger, Karl G.; Byrne, Denis P.; Nummy, Laurence J.; Ridges, Michael D.; Salvagno, Annette
Journal of Heterocyclic Chemistry, 2000 , vol. 37, # 2 p. 229 - 239
反应条件
1: 92.7 percent / sodium hydride; pyridine / 0.5 h / Heating 2: 64.9 percent / tetrakis(triphenylphosphine)palladium / dimethylformamide / 1.5 h / 90 °C View Scheme
参考文献
Grozinger, Karl G.; Byrne, Denis P.; Nummy, Laurence J.; Ridges, Michael D.; Salvagno, Annette
Journal of Heterocyclic Chemistry, 2000 , vol. 37, # 2 p. 229 - 239
反应条件
pyridine; sodium hydride Cyclization; 0.5 h; Heating;
参考文献
Grozinger, Karl G.; Byrne, Denis P.; Nummy, Laurence J.; Ridges, Michael D.; Salvagno, Annette
Journal of Heterocyclic Chemistry, 2000 , vol. 37, # 2 p. 229 - 239
